ArticleAnnals of biomedical engineering2012
Mechanics of a fiber network within a non-fibrillar matrix: model and comparison with collagen-agarose co-gels.
Article in Annals of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of Aging Skin.Journal of biomechanical engineering · 2024Article
- Computational and Experimental Characterization of Aligned Collagen across Varied Crosslinking Degrees.Micromachines · 2024Article
- Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.Communications biology · 2023Article
- A discrete fiber network finite element model of arterial elastin network considering inter-fiber crosslinking property and density.Journal of the mechanical behavior of biomedical materials · 2022Article
- On modeling the multiscale mechanobiology of soft tissues: Challenges and progress.Biophysics reviews · 2022Review
- Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model.Journal of the Royal Society, Interface · 2022Article
- Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading.Journal of biomechanical engineering · 2022Article
- Addition of collagen type I in agarose created a dose-dependent effect on matrix production in engineered cartilage.Regenerative biomaterials · 2022Article
- Evaluation of affine fiber kinematics in porcine tricuspid valve leaflets using polarized spatial frequency domain imaging and planar biaxial testing.Journal of biomechanics · 2021Article
- A 3-D constitutive model for finite element analyses of agarose with a range of gel concentrations.Journal of the mechanical behavior of biomedical materials · 2021Article
- Size Effects in Random Fiber Networks Controlled by the Use of Generalized Boundary Conditions.International journal of solids and structures · 2020Article
- A computational model for understanding the micro-mechanics of collagen fiber network in the tunica adventitia.Biomechanics and modeling in mechanobiology · 2019Article
- Contribution of nascent cohesive fiber-fiber interactions to the non-linear elasticity of fibrin networks under tensile load.Acta biomaterialia · 2019Article
- Helical nanofiber yarn enabling highly stretchable engineered microtissue.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Structural modeling reveals microstructure-strength relationship for human ascending thoracic aorta.Journal of biomechanics · 2018Article
- Poisson's Contraction and Fiber Kinematics in Tissue: Insight From Collagen Network Simulations.Journal of biomechanical engineering · 2018Article
- Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces.Biophysical journal · 2018Article
- Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology.Nature communications · 2017Article
- Mechanical Cell-Cell Communication in Fibrous Networks: The Importance of Network Geometry.Bulletin of mathematical biology · 2017Article
- Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model.Journal of biomechanical engineering · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
While collagen is recognized as the predominant mechanical component of soft connective tissues, the role of the non-fibrillar matrix (NFM) is less well understood. Even model systems, such as the collagen-agarose co-gel, can exhibit complex behavior, making it difficult to identify relative contributions of specific tissue constituents. In the present study, we developed a two-component microscale model of collagen-agarose tissue analogs and used it to elucidate the interaction between collagen and NFM in uniaxial tension. Collagen fibers were represented with Voronoi networks, and the NFM was modeled as a neo-Hookean solid. Model predictions of total normal stress and Poisson's ratio matched experimental observations well (including high Poisson's values of ~3), and the addition of NFM led to composition-dependent decreases in volume change and increases in fiber stretch. Because the NFM was more resistant to volume change than the fiber network, extension of the composite led to pressurization of the NFM. Within a specific range of parameter values (low shear modulus and moderate Poisson's ratio), the magnitude of the reaction force decreased relative to this pressurization component resulting in a negative (compressive) NFM stress in the loading direction, even though the composite tissue was in tension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.