ReviewJournal of mathematical biology2013
A review of spatial computational models for multi-cellular systems, with regard to intestinal crypts and colorectal cancer development.
Review in Journal of mathematical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Tumor heterogeneity: preclinical models, emerging technologies, and future applications.Frontiers in oncology · 2023Review
- J-SPACE: a Julia package for the simulation of spatial models of cancer evolution and of sequencing experiments.BMC bioinformatics · 2022Article
- Esophageal epithelium modeling based on globally coupled map: an approach toward precancerous lesion diagnosis.Medical & biological engineering & computing · 2020Article
- Review
- Optimization of Dose Schedules for Chemotherapy of Early Colon Cancer Determined by High-Performance Computer Simulations.Cancer informatics · 2019Article
- Determining the control networks regulating stem cell lineages in colonic crypts.Journal of theoretical biology · 2017Article
- A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.PLoS computational biology · 2017Article
- Comparing individual-based approaches to modelling the self-organization of multicellular tissues.PLoS computational biology · 2017Article
- Stem cell competition in the gut: insights from multi-scale computational modelling.Journal of the Royal Society, Interface · 2016Article
- Near Equilibrium Calculus of Stem Cells in Application to the Airway Epithelium Lineage.PLoS computational biology · 2016Article
- CABeRNET: a Cytoscape app for augmented Boolean models of gene regulatory NETworks.BMC bioinformatics · 2016Article
- Theoretical cross-comparative analysis on dynamics of small intestine and colon crypts during cancer initiation.IET systems biology · 2015Article
- Multiscale Model of Colorectal Cancer Using the Cellular Potts Framework.Cancer informatics · 2015Article
- CoGNaC: A Chaste Plugin for the Multiscale Simulation of Gene Regulatory Networks Driving the Spatial Dynamics of Tissues and Cancer.Cancer informatics · 2015Article
- Unraveling intestinal stem cell behavior with models of crypt dynamics.Integrative biology : quantitative biosciences from nano to macro · 2014Review
- A mathematical model of the colon crypt capturing compositional dynamic interactions between cell types.International journal of experimental pathology · 2014Article
- Article
- Buckling of a growing tissue and the emergence of two-dimensional patterns.Mathematical biosciences · 2013Article
- Colorectal cancer through simulation and experiment.IET systems biology · 2013Review
- Patterns of proliferative activity in the colonic crypt determine crypt stability and rates of somatic evolution.PLoS computational biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colon rectal cancers (CRC) are the result of sequences of mutations which lead the intestinal tissue to develop in a carcinoma following a "progression" of observable phenotypes. The actual modeling and simulation of the key biological structures involved in this process is of interest to biologists and physicians and, at the same time, it poses significant challenges from the mathematics and computer science viewpoints. In this report we give an overview of some mathematical models for cell sorting (a basic phenomenon that underlies several dynamical processes in an organism), intestinal crypt dynamics and related problems and open questions. In particular, major attention is devoted to the survey of so-called in-lattice (or grid) models and off-lattice (off-grid) models. The current work is the groundwork for future research on semi-automated hypotheses formation and testing about the behavior of the various actors taking part in the adenoma-carcinoma progression, from regulatory processes to cell-cell signaling pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.