ArticlePediatric research2012
Gene expression in sheep carotid arteries: major changes with maturational development.
Article in Pediatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Fetal Cerebral Blood Flow (Dys)autoregulation.Diagnostics (Basel, Switzerland) · 2025Review
- Vascular Stem Cells and the Role of B-Raf Kinase in Survival, Proliferation, and Apoptosis.International journal of molecular sciences · 2023Article
- Angiogenic Transformation in Human Brain Micro Endothelial Cells: Whole Genome DNA Methylation and Transcriptomic Analysis.Frontiers in physiology · 2019Article
- Developmental Maturation and Alpha-1 Adrenergic Receptors-Mediated Gene Expression Changes in Ovine Middle Cerebral Arteries.Scientific reports · 2018Article
- Gene expression profiles and signaling mechanisms in αBMC systems biology · 2017Article
- Comparative and Experimental Studies on the Genes Altered by Chronic Hypoxia in Human Brain Microendothelial Cells.Frontiers in physiology · 2017Article
- Microarray gene expression analysis in ovine ductus arteriosus during fetal development and birth transition.Pediatric research · 2016Article
- Metabolic Profiles in Ovine Carotid Arteries with Developmental Maturation and Long-Term Hypoxia.PloS one · 2015Article
- Angiotensin II-induced cardiovascular load regulates cardiac remodeling and related gene expression in late-gestation fetal sheep.Pediatric research · 2014Article
- The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology.Advances in experimental medicine and biology · 2014Article
- Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity.Current vascular pharmacology · 2013Review
- Antenatal maternal long-term hypoxia: acclimatization responses with altered gene expression in ovine fetal carotid arteries.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWith development from immature fetus to near-term fetus, newborn, and adult, the cerebral vasculature undergoes a number of fundamental changes. Although the near-term fetus is prepared for a transition from an intra- to extra-uterine existence, this is not necessarily the case with the premature fetus, which is more susceptible to cerebrovascular dysregulation. In this study, we tested the hypothesis that the profound developmental and age-related differences in cerebral blood flow are associated with significant underlying changes in gene expression.
methodsWith the use of oligonucleotide microarray and pathway analysis, we elucidated significant changes in the transcriptome with development in sheep carotid arteries.
resultsAs compared with adult, we demonstrate a U-shaped relationship of gene expression in major cerebrovascular network/pathways during early life, e.g., the level of gene expression in the premature fetus and newborn is considerably greater than that of the near-term fetus. Specifically, cell proliferation, growth, and assembly pathway genes were upregulated during early life. In turn, as compared with adult, mitogen-activated protein kinase-extracellular regulated kinase, actin cytoskeleton, and integrin-signaling pathways were downregulated during early life.
conclusionIn cranial vascular smooth muscle, highly significant changes occur in important cellular and signaling pathways with maturational development.
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Registered trials
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