ArticlePediatric research2012
Isoprostanes as physiological mediators of transition to newborn life: novel mechanisms regulating patency of the term and preterm ductus arteriosus.
Article in Pediatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Serum Biomarkers in Patent Ductus Arteriosus in Preterm Infants: A Narrative Review.Biomedicines · 2025Review
- A novel role for PGEAmerican journal of physiology. Heart and circulatory physiology · 2023Article
- Oxygen for the Newborn: Friend or Foe?Children (Basel, Switzerland) · 2023Review
- Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy.Environment international · 2022Article
- Biomarkers of Oxidative Stress for Neonatal Lung Disease.Frontiers in pediatrics · 2021Review
- Patent ductus arteriosus and oxidative stress in preterm infants: a narrative review.Translational pediatrics · 2020Review
- Chemical Compositional Changes in Over-Oxidized Fish Oils.Foods (Basel, Switzerland) · 2020Article
- Molecular and Mechanical Mechanisms Regulating Ductus Arteriosus Closure in Preterm Infants.Frontiers in pediatrics · 2020Review
- Isoprostanes as Biomarker for Patent Ductus Arteriosus in Preterm Infants.Frontiers in pediatrics · 2020Article
- Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation.Pediatric research · 2019Observational
- Understanding the pathobiology in patent ductus arteriosus in prematurity-beyond prostaglandins and oxygen.Pediatric research · 2019Review
- Predictors of successful closure of patent ductus arteriosus with indomethacin.Journal of perinatology : official journal of the California Perinatal Association · 2015Observational
- The isoprostanes--25 years later.Biochimica et biophysica acta · 2015Review
- Prenatal effects of maternal consumption of polyphenol-rich foods in late pregnancy upon fetal ductus arteriosus.Birth defects research. Part C, Embryo today : reviews · 2013Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundIncreased oxygen tension at birth regulates physiologic events that are essential to postnatal survival, but the accompanying oxidative stress may also generate isoprostanes. We hypothesized that isoprostanes regulate ductus arteriosus (DA) function during postnatal vascular transition.
methodsIsoprostanes were measured by gas chromatography-mass spectrometry. DA tone was assessed by pressure myography. Gene expression was measured by quantitative PCR.
resultsOxygen exposure was associated with increased 8-iso-prostaglandin (PG)F2α in newborn mouse lungs. Both 8-iso-PGE2 and 8-iso-PGF2α induced concentration-dependent constriction of the isolated term DA, which was reversed by the thromboxane A2 (TxA2) receptor antagonist SQ29548. SQ29548 pretreatment unmasked an isoprostane-induced DA dilation mediated by the EP4 PG receptor. Exposure of the preterm DA to 8-iso-PGE2 caused unexpected DA relaxation that was reversed by EP4 antagonism. In contrast, exposure to 8-iso-PGF2α caused preterm DA constriction via TxA2 receptor activation. Further investigation revealed the predominance of the TxA2 receptor at term, whereas the EP4 receptor was expressed and functionally active from mid-gestation onward.
conclusionThis study identifies a novel physiological role for isoprostanes during postnatal vascular transition and provide evidence that oxidative stress may act on membrane lipids to produce vasoactive mediators that stimulate physiological DA closure at birth or induce pathological patency of the preterm DA.
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