ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
Safety and feasibility of regadenoson use for suboptimal heart rate response during symptom-limited standard Bruce exercise stress test.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- The EXXERT Study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Trial
- The EXERRT trial: "EXErcise to Regadenoson in Recovery Trial": A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Trial
- Aminophylline and caffeine for reversal of adverse symptoms associated with regadenoson SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Trial
- Regadenoson pharmacologic stress for myocardial perfusion imaging: a three-way comparison between regadenoson administered at peak exercise, during walk recovery, or no-exercise.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Trial
- Safety and feasibility of adjunctive regadenoson injection at peak exercise during exercise myocardial perfusion imaging: The Both Exercise and Regadenoson Stress Test (BERST) trial.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Trial
- Assessment of late-term progression of cardiac allograft vasculopathy in patients with orthotopic heart transplantation using quantitative cardiacThe international journal of cardiovascular imaging · 2021Article
- The impact of combination of regadenoson and isometric exercise on image quality of myocardial perfusion scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Regadenoson stress during low-level exercise: The EXERRT trial-does it move the needle?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Non-invasive assessment of low- and intermediate-risk patients with chest pain.Trends in cardiovascular medicine · 2017Review
- Choosing exercise or pharmacologic stress imaging, or exercise ECG testing alone: How to decide.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric exercise, preliminary results.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- A helping hand for regadenoson tests.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Clinical applications of radionuclide imaging in the evaluation and management of patients with congenital heart disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Value of Exercise ECG for Risk Stratification in Suspected or Known CAD in the Era of Advanced Imaging Technologies.JACC. Cardiovascular imaging · 2015Review
- Does risk for major adverse cardiac events in patients undergoing vasodilator stress with adjunctive exercise differ from patients undergoing either standard exercise or vasodilator stress with myocardial perfusion imaging?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Regadenoson for myocardial perfusion imaging: Is it safe?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Yield of downstream tests after exercise treadmill testing: a prospective cohort study.Journal of the American College of Cardiology · 2014Article
- Is regadenoson an appropriate stressor for MPI in patients with left bundle branch block or pacemakers?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Detection of obstructive coronary artery disease using regadenoson stress and 82Rb PET/CT myocardial perfusion imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
- Regadenoson and exercise myocardial perfusion imaging: the courtship continues.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
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8 authors.
Funding
Abstract
backgroundRegadenoson during exercise stress test (ETT) can provide maximal hyperemia for myocardial perfusion imaging (MPI), along with exercise information. Our aim was to study the feasibility and safety of regadenoson injection at peak ETT for submaximal heart rate (HR) response.
methodsConsecutive patients who underwent SPECT MPI with standard Bruce ETT or supine-regadenoson (Supine-Reg) were analyzed. ETT patients were grouped as ETT-Max [maximal HR > 0.85 * (220 - age), N = 1,522], ETT-Submax (submaximal HR no regadenoson, N = 504), ETT-Reg (submaximal HR and regadenoson, N = 211).
resultsThe HR during ETT was submaximal in 715 (32%) patients. Of these, 211 patients (30%) underwent ETT-Reg (mean exercise duration: 5.5 ± 2.5 minutes). ETT-Reg patients had a higher frequency of hypertension, diabetes, smoking and beta-blocker use, similar rest systolic blood pressure (SBP), but lower rest and peak HR and peak SBP compared to ETT-Max patients. There were no serious complications with regadenoson. Side effects (49% vs 6%, P < .0001) were fewer and aminophylline use was lower with ETT-Reg compared to Supine-Reg (0.5% vs 8.1%, P = .001).
conclusionsSubmaximal HR response to ETT is common. ETT-Reg is safe, feasible, and well-tolerated. ETT-Reg facilitates a diagnostic MPI with reporting of functional capacity, exercise ECG/hemodynamic changes and MPI at maximal hyperemia.
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