ArticleEnvironment international2012
Dietary benzo(a)pyrene and fetal growth: effect modification by vitamin C intake and glutathione S-transferase P1 polymorphism.
Article in Environment international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Polycyclic aromatic hydrocarbons and perinatal outcomes: a scoping review.Pediatric research · 2026Review
- Micronutrients as Mitigators of Endocrine Disrupting Chemical Health Effects: A Scoping Review and Framework for Epidemiologic Studies.Current environmental health reports · 2026Article
- Prenatal chemical exposures and fetal growth: a narrative review of gene-environment interactions (2025).Pediatric research · 2026Review
- Short-Term Exposure to Benzo(a)Pyrene Causes Disruption of GnRH Network in Zebrafish Embryos.International journal of molecular sciences · 2023Article
- Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case-control study from the birth cohort in China.Environmental health : a global access science source · 2022Article
- Dietary Intake and Genetic Background Influence Vitamin Needs during Pregnancy.Healthcare (Basel, Switzerland) · 2022Review
- Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review.Environmental health and preventive medicine · 2022Review
- Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish.Toxicology and applied pharmacology · 2018Article
- Methylmercury Exposure and Developmental Outcomes in Tohoku Study of Child Development at 18 Months of Age.Toxics · 2018Article
- Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea.Public health nutrition · 2016Article
- Postponed effect of neostigmine on oxidative homeostasis.Interdisciplinary toxicology · 2014Article
- Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris).Environmental health perspectives · 2013Article
- Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.Annual review of nutrition · 2013Review
- Impact of nutrition since early life on cardiovascular prevention.Italian journal of pediatrics · 2012Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have reported maternal exposure to airborne polycyclic aromatic hydrocarbons (PAH), as well as DNA adducts reflecting total PAH exposure, to be associated with reduced fetal growth. The role of diet, the main source of PAH exposure among non-smokers, remains uncertain.
objectiveTo assess associations between birth weight, length and small size for gestational age (SGA) with maternal intakes of the genotoxic PAH benzo(a)pyrene [B(a)P] during pregnancy, exploring potential effect modification by dietary intakes of vitamin C, vitamin E, alpha- and beta-carotene, as well as glutathione S-transferase P1 (GSTP1) polymorphisms, hypothesized to influence PAH metabolism.
methods657 women in the INMA (Environment and Childhood) Project from Sabadell (Barcelona) were recruited during the first trimester of pregnancy. Dietary B(a)P and nutrient intakes were estimated from food consumption data. Genotyping was conducted for the Ile105Val variant of GSTP1. Multivariable models were used to assess associations between size at birth and dietary B(a)P, evaluating potential interactions with candidate nutrients and GSTP1 variants.
resultsThere were significant interactions between elevated intakes of vitamin C (above the mean of 189.41 mg/day) and dietary B(a)P during the first trimester of pregnancy in models for birth weight and length (P<0.05), but no interactions were found with other nutrients. B(a)P intakes were associated with significant reductions in birth weight and length (coefficient±SE for a 1-SD increase in B(a)P: -101.63±34.62 g and -0.38±0.16 cm, respectively) among women with low, but not high, vitamin C intakes. Elevated dietary B(a)P was also associated with increased risk of SGA births among women with low dietary vitamin C. Among these women, associations were strongest in those carrying the GSTP1 Val allele, associated with lower contaminant detoxification activity.
conclusionResults suggest that dietary B(a)P exposure may impair fetal growth, particularly in genetically susceptible populations, and that increasing maternal intakes of vitamin C may help to reduce any adverse effects.
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