ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2012
Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Use of oral contraceptives in BRCA mutation carriers and risk for ovarian and breast cancer: a systematic review.Archives of gynecology and obstetrics · 2020Pooled it
- Modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: systematic review and meta-analysis.Journal of the National Cancer Institute · 2014Pooled it
- The importance of ovary-immune interactions in the context of age and disease.Frontiers in neuroendocrinology · 2026Review
- Breast Cancer Risk and Breast-Cancer-Specific Mortality following Risk-Reducing Salpingo-Oophorectomy inCancers · 2023Review
- Review
- Whole-Genome Sequencing IdentifiesCancers · 2022Article
- Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.Journal of the National Cancer Institute · 2019Article
- Review
- GEMO, a National Resource to Study Genetic Modifiers of Breast and Ovarian Cancer Risk inFrontiers in oncology · 2018Article
- Lifetime Number of Ovulatory Cycles and Risks of Ovarian and Endometrial Cancer Among Postmenopausal Women.American journal of epidemiology · 2016Article
- Prophylactic salpingo-oophorectomy in BRCA1 mutation carriers and postoperative incidence of peritoneal and breast cancers.Journal of ovarian research · 2016Article
- iPrevent®: a tailored, web-based, decision support tool for breast cancer risk assessment and management.Breast cancer research and treatment · 2016Article
- Salpingectomy as a means to reduce ovarian cancer risk.Cancer prevention research (Philadelphia, Pa.) · 2015Review
- The relationship between bilateral oophorectomy and plasma hormone levels in postmenopausal women.Hormones & cancer · 2015Article
- Repeated nipple fluid aspiration: compliance and feasibility results from a prospective multicenter study.PloS one · 2015Article
- Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability.Cancer research · 2014Article
- Changes in specialists' perspectives on cancer genetic testing, prophylactic surgery and insurance discrimination: then and now.Journal of genetic counseling · 2014Article
- Lower mitotic activity in BRCA1/2-associated primary breast cancers occurring after risk-reducing salpingo-oophorectomy.Cancer biology & therapy · 2014Article
- Salpingectomy to prevent ovarian cancer: A Countercurrents Series.Current oncology (Toronto, Ont.) · 2013Article
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Authors and funding
24 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundTo evaluate the effect of the cumulative number of ovulatory cycles and its contributing components on the risk of breast cancer among BRCA mutation carriers.
methodsWe conducted a matched case-control study on 2,854 pairs of women with a BRCA1 or BRCA2 mutation. Conditional logistic regression was used to estimate the association between the number of ovulatory cycles and various exposures and the risk of breast cancer. Information from a subset of these women enrolled in a prospective cohort study was used to calculate age-specific breast cancer rates.
resultsThe annual risk of breast cancer decreased with the number of ovulatory cycles experienced (ρ = -0.69; P = 0.03). Age at menarche and duration of breastfeeding were inversely related with risk of breast cancer among BRCA1 (P(trend) < 0.0001) but not among BRCA2 (P(trend) ≥ 0.28) mutation carriers. The reduction in breast cancer risk associated with surgical menopause [OR, 0.52; 95% confidence interval (CI), 0.40-0.66; P(trend) < 0.0001] was greater than that associated with natural menopause (OR, 0.81; 95% CI, 0.62-1.07; P(trend) = 0.14). There was a highly significant reduction in breast cancer risk among women who had an oophorectomy after natural menopause (OR, 0.13; 95% CI, 0.02-0.54; P = 0.006).
conclusionsThese data challenge the hypothesis that breast cancer risk can be predicted by the lifetime number of ovulatory cycles in women with a BRCA mutation. Both pre- and postmenopausal oophorectomy protect against breast cancer. IMPACT: Understanding the basis for the protective effect of oophorectomy has important implications for chemoprevention.
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