ReviewSeminars in immunology2012
Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects.
Review in Seminars in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.PLoS pathogens · 2026Article
- Advanced Medical Countermeasures and Devices for Use During a Radiological or Nuclear Emergency.Disaster medicine and public health preparedness · 2025Review
- How Can We Improve the Vaccination Response in Older People? Part II: Targeting Immunosenescence of Adaptive Immunity Cells.International journal of molecular sciences · 2022Review
- The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice.Immunity & ageing : I & A · 2022Article
- Significant difference in Th1/Th2 paradigm induced by tuberculosis-specific antigens between IGRA-positive and IGRA-negative patients.Frontiers in immunology · 2022Article
- Effect of cellular aging on memory T-cell homeostasis.Frontiers in immunology · 2022Article
- The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections.Frontiers in aging · 2022Review
- Hallmarks of the aging T-cell system.The FEBS journal · 2021Review
- Altered CaInternational journal of molecular sciences · 2020Review
- Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases.Life (Basel, Switzerland) · 2020Article
- Age-Related Lymphocyte Output During Disease-Modifying Therapies for Multiple Sclerosis.Drugs & aging · 2020Observational
- Cytokine Response in SARS-CoV-2 Infection in the Elderly.Journal of inflammation research · 2020Review
- Understanding the Heterogeneous Population of Age-Associated B Cells and Their Contributions to Autoimmunity and Immune Response to Pathogens.Critical reviews in immunology · 2020Article
- Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.Aging cell · 2019Article
- Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?Cell host & microbe · 2019Article
- Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Low-dose radiation accelerates aging of the T-cell receptor repertoire in CBA/Ca mice.Cellular and molecular life sciences : CMLS · 2017Article
- IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Sepsis and Immunosenescence in the Elderly Patient: A Review.Frontiers in medicine · 2017Review
- The aged lymphoid tissue environment fails to support naïve T cell homeostasis.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Our recent studies indicate that the longer peripheral persistence of naïve CD4 T cells that occurs with age is necessary for the development of the key aging defects that lead to compromised responses to vaccination and to new pathogens or new strains of circulating infectious agents. This longer persistence is in turn is linked to the decrease in development of new thymic emigrants and thymic involution that occur at adolescence. Therefore the process of development of naïve CD4 aging defects, is closely tied to the homeostasis of T cells and the shifts that occur in their homeostasis with age. Here we review this connection between age-related changes in T cell homeostasis and the development of T cell defects and discuss the implication for approaches to better vaccinating the elderly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.