Evidence map›Paper›PMID 22564375›Full record

ArticleJournal of thrombosis and haemostasis : JTH2012

Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients.

M P Lambert, A Reznikov, A Grubbs, Y Nguyen, L Xiao, R Aplenc, L Rauova, M Poncz

Registry-linked trialOpen access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02056782 (A Pilot Study to Evaluate the Safety and Preliminary Evidence of an Effect of ODSH), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02056782 phase1completednot on this mapstarted 2013, after this paper: background citation

A Pilot Study to Evaluate the Safety and Preliminary Evidence of an Effect of ODSH (2 O, 3-O Desulfated Heparin) in Accelerating Platelet Recovery in Patients Receiving Induction or Consolidation Therapy for Acute Myeloid Leukemia

TypeinterventionalSponsorJazz PharmaceuticalsRan2013 to 2015Enrolled12ConditionsAcute Myeloid LeukemiaArmsDociparstat sodium
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Autoimmune Heparin-Induced Thrombocytopenia.Journal of clinical medicine · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

M P Lambert
A Reznikov
A Grubbs
Y Nguyen
L Xiao
R Aplenc
L Rauova
M Poncz
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Subcellular Mechanisms pf Platelet ActivationP01HL040387 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, JOEL S. · 1988 to 2018
$35.5M
Protein CoreP01HL110860 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI PONCZ, MORTIMER · 2012 to 2016
$11.4M
Embryonic Stem Cell-Derived Platelets as Cellular TherapeuticsU01HL099656 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI PONCZ, MORTIMER · 2009 to 2015
$8.6M
The mechanism and clinical implications of the negative paracrine effect of PF4K23HL092164 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI LAMBERT, MICHELE P · 2008 to 2012
$781k
NHLBI NIH HHS K23 HL092164NHLBI NIH HHS K23HL092164NHLBI NIH HHS L40 HL082168NHLBI NIH HHS P01 HL040387NHLBI NIH HHS P01HL040387NHLBI NIH HHS P01 HL110860NHLBI NIH HHS U01 HL099656
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Platelet CountPlatelet TransfusionChildFlow CytometryHumansLeukemiaPlatelet Factor 4Platelet Factor 4

Identifiers

PMID22564375
PMCPMC3389572
OpenAlexW1566223007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.