ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2012
Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence, and Inflammation via Toll-like Receptor 4, Reactive Oxygen Species, and p38 MAPK Signaling.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Progesterone SuppressesFrontiers in microbiology · 2021Article
- Identification of microRNAs and their target genes in the placenta as biomarkers of inflammation.Clinical and experimental reproductive medicine · 2020Article
- Progesterone-Related Immune Modulation of Pregnancy and Labor.Frontiers in endocrinology · 2019Review
- Expression of pro-apoptotic markers is increased along the osteochondral junction in naturally occurring osteochondrosis.Bone reports · 2018Article
- Decidual stromal cell-derived PGEAmerican journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2017Review
- Changes in T Cell and Dendritic Cell Phenotype from Mid to Late Pregnancy Are Indicative of a Shift from Immune Tolerance to Immune Activation.Frontiers in immunology · 2017Article
- Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TInternational journal of biological sciences · 2017Article
- Decidual Stromal Cell Necroptosis Contributes to Polyinosinic-Polycytidylic Acid-Triggered Abnormal Murine Pregnancy.Frontiers in immunology · 2017Article
- Do the placental barrier, parasite genotype and Toll-like receptor polymorphisms contribute to the course of primary infection with various Toxoplasma gondii genotypes in pregnant women?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.PloS one · 2014Article
- The role of toll like receptors in pregnancy.International journal of fertility & sterility · 2013Review
- SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Review
- Evidence for a role for the adaptive immune response in human term parturition.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
problemToll-like receptor-4 (TLR-4) protects against Gram-negative bacteria expressed lipopolysaccharide and 'danger signals' from injured or dying cells. Although decidual cells (DCs) and interstitial trophoblasts (ITs) are in close contact, TLR-4 has been studied extensively only in ITs. METHOD OF STUDY: Formalin-fixed, paraffin-embedded serial sections of endometrium in follicular and luteal phases and deciduas from first and second trimester elective terminations and third trimester normal deliveries were immunostained for TLR-4, trophoblast-specific cytokeratin, and DC-specific vimentin. HSCORE assessed TLR-4 immunostaining in DCs versus ITs.
resultsTLR-4 HSCORES were significantly higher in: (i) first trimester DCs than luteal phase pre-decidual stromal cells; (ii) first and third versus second trimester DCs, but similar between third trimester deciduas parietalis and basalis; (iii) first versus second trimester ITs; (iv) DCs versus ITs across gestation.
conclusionHigher TLR-4 in DCs than ITs suggests DCs as primary targets for Gram-negative bacteria and/or inflammation-related danger signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.