ArticleNorth American journal of medicine & science2011
Do Apparent Overlaps between Schizophrenia and Autistic Spectrum Disorders Reflect Superficial Similarities or Etiological Commonalities?
Article in North American journal of medicine & science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Patterns of Nonsocial and Social Cognitive Functioning in Adults With Autism Spectrum Disorder: A Systematic Review and Meta-analysis.JAMA psychiatry · 2019Pooled it
- ERP indices of performance monitoring and feedback processing in psychosis: A meta-analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018Pooled it
- Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- Review
- Validation of the Hebrew version of the Community Assessment of Psychic Experiences in a sample of Israeli Hebrew speakers.Frontiers in psychiatry · 2025Article
- Psychiatric burden in a cohort of adults with Niemann Pick type C disease: from psychotic symptoms to frontal lobe behavioral disorders.Orphanet journal of rare diseases · 2023Article
- Differences in daily life executive functioning between people with autism and people with schizophrenia.Journal of autism and developmental disorders · 2023Article
- Neuropsychological profile of executive functions in autism spectrum disorder and schizophrenia spectrum disorders: a comparative group study in adults.European archives of psychiatry and clinical neuroscience · 2023Article
- Targeting NMDA Receptors at the Neurovascular Unit: Past and Future Treatments for Central Nervous System Diseases.International journal of molecular sciences · 2022Review
- A new multimodality fusion classification approach to explore the uniqueness of schizophrenia and autism spectrum disorder.Human brain mapping · 2022Article
- From Research to Practice: Toward the Examination of Combined Interventions for Autism Spectrum Disorders.Brain sciences · 2021Article
- Face perception predicts affective theory of mind in autism spectrum disorder but not schizophrenia or typical development.Journal of abnormal psychology · 2021Article
- A deep learning fusion model for brain disorder classification: Application to distinguishing schizophrenia and autism spectrum disorder.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2020Article
- Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior?Journal of autism and developmental disorders · 2020Observational
- A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis.Frontiers in psychiatry · 2020Review
- Quantum-like behavior without quantum physics III : Logic and memory.Journal of biological physics · 2019Article
- Clinical Profiles and Conversion Rates Among Young Individuals With Autism Spectrum Disorder Who Present to Clinical High Risk for Psychosis Services.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy.Frontiers in psychiatry · 2019Review
- The morphometric co-atrophy networking of schizophrenia, autistic and obsessive spectrum disorders.Human brain mapping · 2018Article
- Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting Sex- and Age-related Behavioral and Immune/Neurotrophic Alterations in Mice: Relevance to Autism Spectrum Disorders.Molecular neurobiology · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
STUDY
backgroundSchizophrenia and autism are both neurodevelopmental disorders that were once considered to be the same disorder expressed in different developmental periods. Although they were separated diagnostically about 40 years ago, they share several clinical and possibly, etiological features. This paper reviews overlaps in four domains of function to consider the issue of whether these similarities are sporadic and likely to represent superficial similarities, or whether the disorders are more likely to share some features in common.
methodsRepresentative areas of function were reviewed and compared for aspects of cognition (nonverbal reasoning, memory and language), social function (orienting/joint attention, eye contact and theory of mind), brain function (structural differences) and genetics. To facilitate comparisons with schizophrenia, a focus on high functioning autism/Asperger's disorder was utilized, particularly in the sections on cognition and social function.
resultsSignificant similarities (and differences) characterized comparisons in each domain.
conclusionsDisturbed function in similar clinical (in cognition and social function), neurobiological (brain volumes) and genetic (e.g., involvement of the same genes or chromosomal locations) domains in autism and schizophrenia supports the hypothesis that while they are distinct disorders, they are not entirely unique. Additional studies of similarities and differences between them may thus shed light on common etiological mechanisms and hopefully, facilitate the development of novel treatment targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.