Trial reportPloS one2012
Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.Human psychopharmacology · 2022Trial
- No effects of transcranial direct current stimulation on visual evoked potential and peak gamma frequency.Cognitive processing · 2022Trial
- Transcranial direct current stimulation enhances recovery of stereopsis in adults with amblyopia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Trial
- Dissociating mechanisms of spatial suppression and summation in human visual cortical regions MT/V5: a transcranial Direct Current Stimulation (tDCS) study and clinical implications.International review of psychiatry (Abingdon, England) · 2026Article
- Dissociable components of visual perceptual learning characterized by non-invasive brain stimulation: Stage 1 Registered Report.Brain communications · 2025Article
- Visual cortex anodal transcranial direct current stimulation does not alter reading performance for Chinese presented character-by-character to normal peripheral vision in older adults.Frontiers in neuroscience · 2024Article
- Can visual cortex non-invasive brain stimulation improve normal visual function? A systematic review and meta-analysis.Frontiers in neuroscience · 2023Review
- Combined therapy of bilateral transcranial direct current stimulation and ocular occlusion improves visual function in adults with amblyopia, a randomized pilot study.Frontiers in human neuroscience · 2023Article
- Perspectives on the Combined Use of Electric Brain Stimulation and Perceptual Learning in Vision.Vision (Basel, Switzerland) · 2022Article
- Offline transcranial direct current stimulation improves the ability to perceive crowded targets.Journal of vision · 2021Article
- Reorganization of Brain Functional Connectivity Network and Vision Restoration Following Combined tACS-tDCS Treatment After Occipital Stroke.Frontiers in neurology · 2021Article
- Visual cortex cTBS increases mixed percept duration while a-tDCS has no effect on binocular rivalry.PloS one · 2021Article
- Brief localised monocular deprivation in adults alters binocular rivalry predominance retinotopically and reduces spatial inhibition.Scientific reports · 2020Article
- Anodal transcranial direct current stimulation reduces collinear lateral inhibition in normal peripheral vision.PloS one · 2020Article
- Ocular dominance plasticity: inhibitory interactions and contrast equivalence.Scientific reports · 2017Article
- The effect of transcranial direct current stimulation on contrast sensitivity and visual evoked potential amplitude in adults with amblyopia.Scientific reports · 2016Article
- Rehabilitation Approaches in Macular Degeneration Patients.Frontiers in systems neuroscience · 2016Review
- Are Participants Aware of the Type and Intensity of Transcranial Direct Current Stimulation?PloS one · 2016Article
- Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS.Frontiers in cellular neuroscience · 2015Article
- The Effects of tDCS Across the Spatial Frequencies and Orientations that Comprise the Contrast Sensitivity Function.Frontiers in psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial direct current stimulation (tDCS) is a safe, non-invasive technique for transiently modulating the balance of excitation and inhibition within the human brain. It has been reported that anodal tDCS can reduce both GABA mediated inhibition and GABA concentration within the human motor cortex. As GABA mediated inhibition is thought to be a key modulator of plasticity within the adult brain, these findings have broad implications for the future use of tDCS. It is important, therefore, to establish whether tDCS can exert similar effects within non-motor brain areas. The aim of this study was to assess whether anodal tDCS could reduce inhibitory interactions within the human visual cortex. Psychophysical measures of surround suppression were used as an index of inhibition within V1. Overlay suppression, which is thought to originate within the lateral geniculate nucleus (LGN), was also measured as a control. Anodal stimulation of the occipital poles significantly reduced psychophysical surround suppression, but had no effect on overlay suppression. This effect was specific to anodal stimulation as cathodal stimulation had no effect on either measure. These psychophysical results provide the first evidence for tDCS-induced reductions of intracortical inhibition within the human visual cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.