ArticlePloS one2012
Mechanisms of endothelial dysfunction in resistance arteries from patients with end-stage renal disease.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Systemic microvascular dysfunction in microvascular and vasospastic angina.European heart journal · 2018Trial
- Total parathyroidectomy with autotransplantation vs. subtotal parathyroidectomy for secondary hyperparathyroidism: lower recurrence rates but comparable cardiovascular outcomes.American journal of translational research · 2026Article
- Indoxyl Sulphate Retention Is Associated with Microvascular Endothelial Dysfunction after Kidney Transplantation.International journal of molecular sciences · 2023Article
- Hypertension in chronic kidney disease: What lies behind the scene.Frontiers in pharmacology · 2022Review
- Review
- Uremic Toxins and Vascular Dysfunction.Toxins · 2020Review
- Skin microvascular dysfunction as an early cardiovascular marker in primary hyperoxaluria type I.Pediatric nephrology (Berlin, Germany) · 2019Article
- Klotho and Postmenopausal Hormone Replacement Therapy in Women with Chronic Kidney Disease.Journal of menopausal medicine · 2018Review
- Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Long chain n-3 polyunsaturated fatty acids and vascular function in patients with chronic kidney disease and healthy subjects: a cross-sectional and comparative study.BMC nephrology · 2016Article
- Nitric Oxide Resistance Reduces Arteriovenous Fistula Maturation in Chronic Kidney Disease in Rats.PloS one · 2016Article
- Exaggerated blood pressure response to dynamic exercise despite chronic refractory hypotension: results of a human case study.BMC nephrology · 2015Article
- αKlotho and vascular calcification: an evolving paradigm.Current opinion in nephrology and hypertension · 2014Review
- Article
- Hemodynamics and function of resistance arteries in healthy persons and end stage renal disease patients.PloS one · 2014Article
- Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats.Physiological reports · 2013Article
- Endothelial cell transfusion ameliorates endothelial dysfunction in 5/6 nephrectomized rats.American journal of physiology. Heart and circulatory physiology · 2013Article
- Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The study focuses on the mechanisms of endothelial dysfunction in the uremic milieu. Subcutaneous resistance arteries from 35 end-stage renal disease (ESRD) patients and 28 matched controls were studied ex-vivo. Basal and receptor-dependent effects of endothelium-derived factors, expression of endothelial NO synthase (eNOS), prerequisites for myoendothelial gap junctions (MEGJ), and associations between endothelium-dependent responses and plasma levels of endothelial dysfunction markers were assessed. The contribution of endothelium-derived hyperpolarizing factor (EDHF) to endothelium-dependent relaxation was impaired in uremic arteries after stimulation with bradykinin, but not acetylcholine, reflecting the agonist-specific differences. Diminished vasodilator influences of the endothelium on basal tone and enhanced plasma levels of asymmetrical dimethyl L-arginine (ADMA) suggest impairment in NO-mediated regulation of uremic arteries. eNOS expression and contribution of MEGJs to EDHF type responses were unaltered. Plasma levels of ADMA were negatively associated with endothelium-dependent responses in uremic arteries. Preserved responses of smooth muscle to pinacidil and NO-donor indicate alterations within the endothelium and tolerance of vasodilator mechanisms to the uremic retention products at the level of smooth muscle. We conclude that both EDHF and NO pathways that control resistance artery tone are impaired in the uremic milieu. For the first time, we validate the alterations in EDHF type responses linked to kinin receptors in ESRD patients. The association between plasma ADMA concentrations and endothelial function in uremic resistance vasculature may have diagnostic and future therapeutic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.