ArticlePloS one2012
Molecular subtype classification is a determinant of non-sentinel lymph node metastasis in breast cancer patients with positive sentinel lymph nodes.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Applying a multi-task and multi-instance framework to predict axillary lymph node metastases in breast cancer.NPJ precision oncology · 2025Article
- Preoperative ultrasonography-guided core-needle biopsy-based factors for predicting the upgrade of axillary lymph nodes in breast cancer.Quantitative imaging in medicine and surgery · 2025Article
- Predicting sentinel lymph node metastasis in breast cancer: a study based on the SEER database.Clinical and experimental medicine · 2025Article
- A preoperative prediction model for ipsilateral axillary lymph node metastasis of breast cancer based on clinicopathological and ultrasonography features: a prospective cohort study.Frontiers in oncology · 2025Article
- A nomogram model for predicting the risk of axillary lymph node metastasis in patients with early breast cancer and cN0 status.Oncology letters · 2024Article
- Ultrasonography and clinicopathological features of breast cancer in predicting axillary lymph node metastases.BMC cancer · 2022Article
- Relation Between Tumor Size and Lymph Node Metastasis According to Subtypes of Breast Cancer.Journal of breast cancer · 2021Article
- Imaging Predictors for Nonsentinel Lymph Node Metastases in Breast Cancer Patients.Breast care (Basel, Switzerland) · 2020Article
- Increased Stromal Infiltrating Lymphocytes are Associated with Circulating Tumor Cells and Metastatic Relapse in Breast Cancer Patients After Neoadjuvant Chemotherapy.Cancer management and research · 2019Article
- Analysis of factors related to non-sentinel lymph node metastasis in 296 sentinel lymph node-positive Chinese breast cancer patients.Cancer biology & medicine · 2018Article
- Factors Influencing Non-sentinel Node Metastasis in Patients with Macrometastatic Sentinel Lymph Node Involvement and Validation of Three Commonly Used Nomograms.European journal of breast health · 2017Article
- Article
- Locoregional treatment of early breast cancer with isolated tumor cells or micrometastases on sentinel lymph node biopsy.World journal of clinical oncology · 2016Review
- Breast Cancer Subtype is Associated With Axillary Lymph Node Metastasis: A Retrospective Cohort Study.Medicine · 2015Article
- Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer.Diagnostic pathology · 2015Article
- Breast Cancer Subtype as a Predictor of Lymph Node Metastasis according to the SEER Registry.Journal of breast cancer · 2015Article
- Prediction of macrometastasis in axillary lymph nodes of patients with invasive breast cancer and the utility of the SUV lymph node/tumor ratio using FDG-PET/CT.World journal of surgical oncology · 2015Article
- Subtype is a predictive factor of nonsentinel lymph node involvement in sentinel node-positive breast cancer patients.Journal of breast cancer · 2014Article
- Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study.BMC cancer · 2014Article
- In breast cancer patients sentinel lymph node metastasis characteristics predict further axillary involvement.Virchows Archiv : an international journal of pathology · 2014Article
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9 authors.
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Abstract
backgroundPrevious studies suggested that the molecular subtypes were strongly associated with sentinel lymph node (SLN) status. The purpose of this study was to determine whether molecular subtype classification was associated with non-sentinel lymph nodes (NSLN) metastasis in patients with a positive SLN. METHODOLOGY AND PRINCIPAL
findingsBetween January 2001 and March 2011, a total of 130 patients with a positive SLN were recruited. All these patients underwent a complete axillary lymph node dissection. The univariate and multivariate analyses of NSLN metastasis were performed. In univariate and multivariate analyses, large tumor size, macrometastasis and high tumor grade were all significant risk factors of NSLN metastasis in patients with a positive SLN. In univariate analysis, luminal B subgroup showed higher rate of NSLN metastasis than other subgroup (P = 0.027). When other variables were adjusted in multivariate analysis, the molecular subtype classification was a determinant of NSLN metastasis. Relative to triple negative subgroup, both luminal A (P = 0.047) and luminal B (P = 0.010) subgroups showed a higher risk of NSLN metastasis. Otherwise, HER2 over-expression subgroup did not have a higher risk than triple negative subgroup (P = 0.183). The area under the curve (AUC) value was 0.8095 for the Cambridge model. When molecular subtype classification was added to the Cambridge model, the AUC value was 0.8475.
conclusionsExcept for other factors, molecular subtype classification was a determinant of NSLN metastasis in patients with a positive SLN. The predictive accuracy of mathematical models including molecular subtype should be determined in the future.
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