SynthesisPloS one2012
Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 880 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of a Barrier Enclosure on Endotracheal Intubation Duration and First Pass Attempt - A Randomized Controlled Trial
Effect of Using Barrier Devices for Intubation in COVID-19 Patients: Randomized, Prospective, Manikin Study
SARS-CoV-2 PANDEMIC AND FAILED SPINAL ANESTHESIA: A NIGHTMARE
Evaluation of Leak-free Bronchoscope Adapter to Limit Ventilated Air Volume Loss and Pathogen Aerosolization From Intubated Patients Who Receive Bronchoscopy
Who cites it
880 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Skin Problems in the Facial Area due to the Use of Personal Protective Equipment in Healthcare Workers: A Systematic Review.Journal of clinical nursing · 2025Pooled it
- Efficacy of simulation-based training for airway management in preparing hospitals for the COVID-19 pandemic: a systematic review.Frontiers in medicine · 2025Pooled it
- The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Molecular Diagnostic Testing (December 2023).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Guideline
- Generation of Aerosols by Noninvasive Respiratory Support Modalities: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- Early intubation and clinical outcomes in patients with severe COVID-19: a systematic review and meta-analysis.European journal of medical research · 2022Pooled it
- Risk of transmission of respiratory viruses during aerosol-generating medical procedures (AGMPs) revisited in the COVID-19 pandemic: a systematic review.Antimicrobial resistance and infection control · 2022Pooled it
- Meta-analysis of COVID-19 prevalence during preoperative COVID-19 screening in asymptomatic patients.BMJ open · 2022Pooled it
- SARS-CoV-2 transmission risk to healthcare workers performing tracheostomies: a systematic review.ANZ journal of surgery · 2022Pooled it
- Cuffed versus uncuffed endotracheal tubes for neonates.The Cochrane database of systematic reviews · 2022Pooled it
- Aerosol Box Use in Reducing Health Care Worker Contamination During Airway Procedures (AIRWAY Study): A Simulation-Based Randomized Clinical Trial.JAMA network open · 2023Trial
- Evaluation of the conventional and modified aerosol boxes during tracheal intubation in normal and difficult airways: a randomized, crossover, manikin simulation study.Journal of clinical monitoring and computing · 2022Trial
- Investigation of the optimal method of oxygen administration with simultaneous use of a surgical mask: a randomized control study.Journal of anesthesia · 2022Trial
- Accounting for the long-distance transmission route: An epidemiological model of airborne disease transmission in hospitals.PLoS computational biology · 2026Article
- Seven-year surveillance of latent tuberculosis infection using interferon-gamma release assay among health workers at a large tertiary hospital in Thailand.Journal of occupational medicine and toxicology (London, England) · 2026Article
- The effect of the COVID-19 pandemic on orthognathic surgery in Sweden - a registry-based study.BMC oral health · 2026Article
- Characterization of aerosols generated during suspected aerosol-generating procedures in healthcare settings.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Impact of COVID-19 on management and outcomes of NHS patients with recurrent respiratory papillomatosis: evidence from a UK registry.Annals of the Royal College of Surgeons of England · 2026Article
- Article
- Comparison of Aerosol Generation Between Bag Valve and Chest Compression-Synchronized Ventilation During Simulated Cardiopulmonary Resuscitation.Journal of clinical medicine · 2025Article
- A randomised controlled trial comparing epinephrine and dexamethasone to placebo in the treatment of infants with bronchiolitis: the Bronchiolitis in Infants PlaceboERJ open research · 2025Article
820 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aerosol generating procedures (AGPs) may expose health care workers (HCWs) to pathogens causing acute respiratory infections (ARIs), but the risk of transmission of ARIs from AGPs is not fully known. We sought to determine the clinical evidence for the risk of transmission of ARIs to HCWs caring for patients undergoing AGPs compared with the risk of transmission to HCWs caring for patients not undergoing AGPs. We searched PubMed, EMBASE, MEDLINE, CINAHL, the Cochrane Library, University of York CRD databases, EuroScan, LILACS, Indian Medlars, Index Medicus for SE Asia, international health technology agencies and the Internet in all languages for articles from 01/01/1990 to 22/10/2010. Independent reviewers screened abstracts using pre-defined criteria, obtained full-text articles, selected relevant studies, and abstracted data. Disagreements were resolved by consensus. The outcome of interest was risk of ARI transmission. The quality of evidence was rated using the GRADE system. We identified 5 case-control and 5 retrospective cohort studies which evaluated transmission of SARS to HCWs. Procedures reported to present an increased risk of transmission included [n; pooled OR(95%CI)] tracheal intubation [n = 4 cohort; 6.6 (2.3, 18.9), and n = 4 case-control; 6.6 (4.1, 10.6)], non-invasive ventilation [n = 2 cohort; OR 3.1(1.4, 6.8)], tracheotomy [n = 1 case-control; 4.2 (1.5, 11.5)] and manual ventilation before intubation [n = 1 cohort; OR 2.8 (1.3, 6.4)]. Other intubation associated procedures, endotracheal aspiration, suction of body fluids, bronchoscopy, nebulizer treatment, administration of O2, high flow O2, manipulation of O2 mask or BiPAP mask, defibrillation, chest compressions, insertion of nasogastric tube, and collection of sputum were not significant. Our findings suggest that some procedures potentially capable of generating aerosols have been associated with increased risk of SARS transmission to HCWs or were a risk factor for transmission, with the most consistent association across multiple studies identified with tracheal intubation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.