ArticlePloS one2012
The dopamine D2 receptor gene in lamprey, its expression in the striatum and cellular effects of D2 receptor activation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Differences in the Effect of Dopamine on the Phototransduction Between Lampreys and Jawed Vertebrates.International journal of molecular sciences · 2026Article
- Convergent Evolution of Two Dopamine Receptor Genes: Repeated Evolution of Exon 6 Skipping in Drd2, and Repeated Deletion of Exon 6 in Drd3.Journal of molecular evolution · 2025Article
- Olfactory Projections to Locomotor Control Centers in the Sea Lamprey.International journal of molecular sciences · 2024Article
- The neural bases of vertebrate motor behaviour through the lens of evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The Dopaminergic Control of Movement-Evolutionary Considerations.International journal of molecular sciences · 2021Review
- Article
- Dopaminergic modulation of olfactory-evoked motor output in sea lampreys (Petromyzon marinus L.).The Journal of comparative neurology · 2020Article
- Nigral Glutamatergic Neurons Control the Speed of Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- A descending dopamine pathway conserved from basal vertebrates to mammals.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cloning of the GABAFrontiers in neuroanatomy · 2016Article
- Full anatomical recovery of the dopaminergic system after a complete spinal cord injury in lampreys.Neural plasticity · 2015Article
- Expression of a Novel D4 Dopamine Receptor in the Lamprey Brain. Evolutionary Considerations about Dopamine Receptors.Frontiers in neuroanatomy · 2015Article
- Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates.Frontiers in neuroscience · 2015Article
- The evolutionary origin of the vertebrate basal ganglia and its role in action selection.The Journal of physiology · 2013Article
- Independent circuits in the basal ganglia for the evaluation and selection of actions.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Forebrain dopamine neurons project down to a brainstem region controlling locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Evolutionarily conserved differences in pallial and thalamic short-term synaptic plasticity in striatum.The Journal of physiology · 2013Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
All basal ganglia subnuclei have recently been identified in lampreys, the phylogenetically oldest group of vertebrates. Furthermore, the interconnectivity of these nuclei is similar to mammals and tyrosine hydroxylase-positive (dopaminergic) fibers have been detected within the input layer, the striatum. Striatal processing is critically dependent on the interplay with the dopamine system, and we explore here whether D2 receptors are expressed in the lamprey striatum and their potential role. We have identified a cDNA encoding the dopamine D2 receptor from the lamprey brain and the deduced protein sequence showed close phylogenetic relationship with other vertebrate D2 receptors, and an almost 100% identity within the transmembrane domains containing the amino acids essential for dopamine binding. There was a strong and distinct expression of D2 receptor mRNA in a subpopulation of striatal neurons, and in the same region tyrosine hydroxylase-immunoreactive synaptic terminals were identified at the ultrastructural level. The synaptic incidence of tyrosine hydroxylase-immunoreactive boutons was highest in a region ventrolateral to the compact layer of striatal neurons, a region where most striatal dendrites arborise. Application of a D2 receptor agonist modulates striatal neurons by causing a reduced spike discharge and a diminished post-inhibitory rebound. We conclude that the D2 receptor gene had already evolved in the earliest group of vertebrates, cyclostomes, when they diverged from the main vertebrate line of evolution (560 mya), and that it is expressed in striatum where it exerts similar cellular effects to that in other vertebrates. These results together with our previous published data (Stephenson-Jones et al. 2011, 2012) further emphasize the high degree of conservation of the basal ganglia, also with regard to the indirect loop, and its role as a basic mechanism for action selection in all vertebrates.
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