ArticleFrontiers in genetics2012
Beyond modeling: all-atom olfactory receptor model simulations.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.Cellular and molecular life sciences : CMLS · 2020Article
- Understanding Ligand Binding to G-Protein Coupled Receptors Using Multiscale Simulations.Frontiers in molecular biosciences · 2019Review
- Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research.Current neuropharmacology · 2019Article
- Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1.Cellular and molecular life sciences : CMLS · 2017Article
- Agonist Binding to Chemosensory Receptors: A Systematic Bioinformatics Analysis.Frontiers in molecular biosciences · 2017Article
- ORDB, HORDE, ODORactor and other on-line knowledge resources of olfactory receptor-odorant interactions.Database : the journal of biological databases and curation · 2016Article
- Computational Approaches for Decoding Select Odorant-Olfactory Receptor Interactions Using Mini-Virtual Screening.PloS one · 2015Article
- Predicted 3D structures of olfactory receptors with details of odorant binding to OR1G1.Journal of computer-aided molecular design · 2014Article
- Preferential binding of an odor within olfactory receptors: a precursor to receptor activation.Chemical senses · 2014Article
- Databases in SenseLab for the genomics, proteomics, and function of olfactory receptors.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
Olfactory receptors (ORs) are a type of GTP-binding protein-coupled receptor (GPCR). These receptors are responsible for mediating the sense of smell through their interaction with odor ligands. OR-odorant interactions marks the first step in the process that leads to olfaction. Computational studies on model OR structures can generate focused and novel hypotheses for further bench investigation by providing a view of these interactions at the molecular level beyond inferences that are drawn merely from static docking. Here we have shown the specific advantages of simulating the dynamic environment associated with OR-odorant interactions. We present a rigorous protocol which ranges from the creation of a computationally derived model of an olfactory receptor to simulating the interactions between an OR and an odorant molecule. Given the ubiquitous occurrence of GPCRs in the membranes of cells, we anticipate that our OR-developed methodology will serve as a model for the computational structural biology of all GPCRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.