ArticleFrontiers in immunology2012
A Basal chordate model for studies of gut microbial immune interactions.
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Vanadium Accumulation and Reduction by Vanadium-Accumulating Bacteria Isolated from the Intestinal Contents of Ciona robusta.Marine biotechnology (New York, N.Y.) · 2024Article
- Article
- Transcriptional and proteomic analysis of the innate immune response to microbial stimuli in a model invertebrate chordate.Frontiers in immunology · 2023Article
- Cultivation of gut microorganisms of the marine ascidianMarine life science & technology · 2022Article
- Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology.Immunogenetics · 2022Review
- Reflections on the Use of an Invertebrate Chordate Model System for Studies of Gut Microbial Immune Interactions.Frontiers in immunology · 2021Review
- Diversity, Bioactivity Profiling and Untargeted Metabolomics of the Cultivable Gut Microbiota ofMarine drugs · 2020Article
- Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution.Science immunology · 2020Article
- A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains.Frontiers in immunology · 2019Article
- Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis.Biology open · 2018Article
- Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria.Nature communications · 2016Article
- Immune-directed support of rich microbial communities in the gut has ancient roots.Developmental and comparative immunology · 2014Review
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- Article
- Changing views of the evolution of immunity.Frontiers in immunology · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Complex symbiotic interactions at the surface of host epithelia govern most encounters between host and microbe. The epithelium of the gut is a physiologically ancient structure that is comprised of a single layer of cells and is thought to possess fully developed immunological capabilities. Ciona intestinalis (sea squirt), which is a descendant of the last common ancestor of all vertebrates, is a potentially valuable model for studying barrier defenses and gut microbial immune interactions. A variety of innate immunological phenomena have been well characterized in Ciona, of which many are active in the gut tissues. Interactions with gut microbiota likely involve surface epithelium, secreted immune molecules including variable region-containing chitin-binding proteins, and hemocytes from a densely populated laminar tissue space. The microbial composition of representative gut luminal contents has been characterized by molecular screening and a potentially relevant, reproducible, dysbiosis can be induced via starvation. The dialog between host and microbe in the gut can be investigated in Ciona against the background of a competent innate immune system and in the absence of the integral elements and processes that are characteristic of vertebrate adaptive immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.