ArticleFrontiers in physiology2012
Activation of brainstem neurons by underwater diving in the rat.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Medullary dorsal horn neurons activated during voluntary diving express neurotransmitter receptors for glutamate and substance P.IBRO neuroscience reports · 2026Article
- Lactate increases oxygen unloading of preconditioned blood from male elite breath-hold divers.Physiological reports · 2026Article
- The nucleus tractus solitarii across vertebrates: developmental origins, comparative organization, and supranuclear modulation in humans.Frontiers in integrative neuroscience · 2026Review
- Nasal trigeminal projections and medullary dorsal horn neuronal activation during voluntary diving in rats.Frontiers in physiology · 2025Article
- Controls of Central and Peripheral Blood Pressure and Hemorrhagic/Hypovolemic Shock.Journal of clinical medicine · 2023Review
- Air Pollution-Induced Autonomic Modulation.Physiology (Bethesda, Md.) · 2020Review
- The Mammalian Diving Response: Inroads to Its Neural Control.Frontiers in neuroscience · 2020Review
- A robust diving response in the laboratory mouse.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Restoration of the nasopharyngeal response after bilateral sectioning of the anterior ethmoidal nerve in the rat.Physiological reports · 2018Article
- An explanation for sudden death in epilepsy (SUDEP).The journal of physiological sciences : JPS · 2018Review
- Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response.Frontiers in neuroanatomy · 2018Article
- Seizure-associated central apnea in a rat model: Evidence for resetting the respiratory rhythm and activation of the diving reflex.Neurobiology of disease · 2017Article
- Afferent and efferent connections of C1 cells with spinal cord or hypothalamic projections in mice.Brain structure & function · 2016Article
- The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Review
- Diving Response in Rats: Role of the Subthalamic Vasodilator Area.Frontiers in neurology · 2016Article
- Repetitive Diving in Trained Rats Still Increases Fos Production in Brainstem Neurons after Bilateral Sectioning of the Anterior Ethmoidal Nerve.Frontiers in physiology · 2016Article
- Article
- Training rats to voluntarily dive underwater: investigations of the mammalian diving response.Journal of visualized experiments : JoVE · 2014Article
- Direct reticular projections of trigeminal sensory fibers immunoreactive to CGRP: potential monosynaptic somatoautonomic projections.Frontiers in neuroscience · 2014Article
- Parasympathetic preganglionic cardiac motoneurons labeled after voluntary diving.Frontiers in physiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian diving response is a powerful autonomic adjustment to underwater submersion greatly affecting heart rate, arterial blood pressure, and ventilation. The bradycardia is mediated by the parasympathetic nervous system, arterial blood pressure is mediated via the sympathetic system and still other circuits mediate the respiratory changes. In the present study we investigate the cardiorespiratory responses and the brainstem neurons activated by voluntary diving of trained rats, and, compare them to control and swimming animals which did not dive. We show that the bradycardia and increase in arterial blood pressure induced by diving were significantly different than that induced by swimming. Neuronal activation was calculated after immunohistochemical processing of brainstem sections for Fos protein. Labeled neurons were counted in the caudal pressor area, the medullary dorsal horn, subnuclei of the nucleus tractus solitarii (NTS), the nucleus raphe pallidus (RPa), the rostroventrolateral medulla, the A5 area, the nucleus locus coeruleus, the Kölliker-Fuse area, and the external lateral and superior lateral subnuclei of the parabrachial nucleus. All these areas showed significant increases in Fos labeling when data from voluntary diving rats were compared to control rats and all but the commissural subnucleus of the NTS, A5 area, and RPa were significantly different from swimming rats. These data provide a substrate for more precise experiments to determine the role of these nuclei in the reflex circuits driving the diving response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.