ArticleJournal of non-Newtonian fluid mechanics2011
The consequences of yield stress on deployment of a non-Newtonian anti-HIV microbicide gel.
Article in Journal of non-Newtonian fluid mechanics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Trial
- Entrance effects and high shear rate rheology of shear banding wormlike micelle fluids in a microcapillary flow.Journal of rheology · 2020Article
- Vaginal drug distribution modeling.Advanced drug delivery reviews · 2015Review
- Vaginal deployment and tenofovir delivery by microbicide gels.Drug delivery and translational research · 2015Article
- Gravity-Driven Thin Film Flow of an Ellis Fluid.Journal of non-Newtonian fluid mechanics · 2013Article
- Manipulating biological agents and cells in micro-scale volumes for applications in medicine.Chemical Society reviews · 2013Review
- Transient swelling, spreading, and drug delivery by a dissolved anti-HIV microbicide-bearing film.Physics of fluids (Woodbury, N.Y. : 1994) · 2013Article
- Transient spreading and swelling behavior of a gel deploying an anti-HIV topical microbicide.Journal of non-Newtonian fluid mechanics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A recent study in South Africa has confirmed, for the first time, that a vaginal gel formulation of the antiretroviral drug Tenofovir, when applied topically, significantly inhibits sexual HIV transmission to women [10]. However the gel for this drug, and anti-HIV microbicide gels in general, have not been designed using full understanding of how gel spreading and retention in the vagina govern successful drug delivery. Elastohydrodynamic lubrication theory can be applied to model such spreading of microbicide gels, which are inherently non-Newtonian [13,15]. A yield stress is emerging as one of the important properties of microbicide gel vehicle deployment, as this may improve retention within the vaginal canal. On the other hand, a yield stress may decrease the initial extent of the coating flow. Here, we first explain a certain yield stress paradox observed generally in many lubrication flows. Four conditions are determined, via scaling analysis, which mitigate the inconsistency in the use of lubrication theory to analyze the specific problem of elastic wall squeezing flow of yield stress fluid. Parameters characterizing these conditions are obtained experimentally for a test gel. Using them, it is shown that the lubrication approximation may be applied to the elastic wall-squeezing problem for this gel.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.