ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2013
SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Plasma metabolites may inhibit childhood obesity by regulating ferroptosis through SMPD1 and SIRT3.International journal of obesity (2005) · 2026Article
- Role of SIRT3 in digestive system diseases and therapeutic prospects (Review).International journal of molecular medicine · 2026Review
- Therapeutic Potential of Irisin in Neurodegenerative Diseases.International journal of molecular sciences · 2025Review
- Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome.Scientific reports · 2022Article
- Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.Biochimica et biophysica acta. Molecular basis of disease · 2020Article
- Duodenal-Jejunal Bypass Surgery Stimulates the Expressions of Hepatic Sirtuin1 and 3 and Hypothalamic Sirtuin1.Journal of obesity & metabolic syndrome · 2018Article
- A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway.Journal of translational medicine · 2017Article
- Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction.Molecular and cellular biochemistry · 2016Article
- Contribution of mitochondrial oxidative stress to hypertension.Current opinion in nephrology and hypertension · 2016Review
- LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways.Scientific reports · 2016Article
- Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development.Scientific reports · 2015Article
- Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice.Metabolism: clinical and experimental · 2015Article
- Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.Physiological reviews · 2014Review
- Impact of various exercise modalities on hepatic mitochondrial function.Medicine and science in sports and exercise · 2014Article
- Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.American journal of physiology. Heart and circulatory physiology · 2014Article
- Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells.PloS one · 2014Article
- BET1L and TNRC6B associate with uterine fibroid risk among European Americans.Human genetics · 2013Article
- Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction.Molecules and cells · 2013Review
- Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
Corrections and comments
- Comment on
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eating a "Western diet" high in fat and sugars is associated with accelerated development of age-related metabolic diseases such as obesity, insulin resistance, and diabetes while incidences of these diseases are decreased on a low-calorie diet. The mitochondrial NAD(+)-dependent protein deacetylase SIRT3 has previously been shown to be important in adapting to metabolic stress brought on by fasting and calorie restriction. During times of metabolic stress, SIRT3 is upregulated and maintains homeostasis following nutrient deprivation by turning on pathways such as fatty acid oxidation, antioxidant production, and the urea cycle. New studies now demonstrate that SIRT3 is regulated during nutrient excess. During high-fat diet feeding, SIRT3 is downregulated leading to mitochondrial protein hyperacetylation. The consequence of this hyperacetylation is the accelerated development of metabolic syndrome. Thus, SIRT3 is emerging as an important metabolic sensor working to restore metabolic homeostasis during times of stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.