ArticleGenetics2012
Fine-scale maps of recombination rates and hotspots in the mouse genome.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed.
- PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish.PLoS biology · 2025Article
- Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis: A model based exploration of the PRDM9 intra-genomic Red Queen.PLoS genetics · 2024Article
- Exploration of Genome-Wide Recombination Rate Variation Patterns at Different Scales in Pigs.Animals : an open access journal from MDPI · 2024Article
- Novel Insights into the Landscape of Crossover and Noncrossover Events in Rhesus Macaques (Macaca mulatta).Genome biology and evolution · 2024Article
- AP-1-independent NFAT signaling maintains follicular T cell function in infection and autoimmunity.The Journal of experimental medicine · 2023Article
- Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse (Mus musculus) Populations.Molecular biology and evolution · 2023Article
- Domestication Shapes Recombination Patterns in Tomato.Molecular biology and evolution · 2022Article
- Genetic variation in recombination rate in the pig.Genetics, selection, evolution : GSE · 2021Article
- Meiosis and beyond - understanding the mechanistic and evolutionary processes shaping the germline genome.Biological reviews of the Cambridge Philosophical Society · 2021Review
- Regulation of Meiotic Prophase One in Mammalian Oocytes.Frontiers in cell and developmental biology · 2021Review
- Genetic differentiation and intrinsic genomic features explain variation in recombination hotspots among cocoa tree populations.BMC genomics · 2020Article
- Population Genomics of the House Mouse and the Brown Rat.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Exploration of fine-scale recombination rate variation in the domestic horse.Genome research · 2019Article
- A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination.Nature communications · 2019Article
- Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish.Genome biology and evolution · 2019Article
- Meiocyte-Specific and AtSPO11-1-Dependent Small RNAs and Their Association with Meiotic Gene Expression and Recombination.The Plant cell · 2019Article
- Identification of recombination hotspots and quantitative trait loci for recombination rate in layer chickens.Journal of animal science and biotechnology · 2019Article
- Genome wide association analysis in a mouse advanced intercross line.Nature communications · 2018Article
- In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Structured illumination microscopy imaging reveals localization of replication protein A between chromosome lateral elements during mammalian meiosis.Experimental & molecular medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Recombination events are not uniformly distributed and often cluster in narrow regions known as recombination hotspots. Several studies using different approaches have dramatically advanced our understanding of recombination hotspot regulation. Population genetic data have been used to map and quantify hotspots in the human genome. Genetic variation in recombination rates and hotspots usage have been explored in human pedigrees, mouse intercrosses, and by sperm typing. These studies pointed to the central role of the PRDM9 gene in hotspot modulation. In this study, we used single nucleotide polymorphisms (SNPs) from whole-genome resequencing and genotyping studies of mouse inbred strains to estimate recombination rates across the mouse genome and identified 47,068 historical hotspots--an average of over 2477 per chromosome. We show by simulation that inbred mouse strains can be used to identify positions of historical hotspots. Recombination hotspots were found to be enriched for the predicted binding sequences for different alleles of the PRDM9 protein. Recombination rates were on average lower near transcription start sites (TSS). Comparing the inferred historical recombination hotspots with the recent genome-wide mapping of double-strand breaks (DSBs) in mouse sperm revealed a significant overlap, especially toward the telomeres. Our results suggest that inbred strains can be used to characterize and study the dynamics of historical recombination hotspots. They also strengthen previous findings on mouse recombination hotspots, and specifically the impact of sequence variants in Prdm9.
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