ReviewImmunologic research2012
Mononuclear phagocyte diversity in the intestine.
Review in Immunologic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease.Nature microbiology · 2021Article
- Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis.Science translational medicine · 2018Article
- Communication Between the Microbiota and Mammalian Immunity.Annual review of microbiology · 2018Review
- Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV.Mucosal immunology · 2017Article
- Pathogenesis of NEC: Role of the innate and adaptive immune response.Seminars in perinatology · 2017Review
- Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.Cell · 2016Article
- Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells.Mucosal immunology · 2016Article
- Innate lymphoid cells in intestinal immunity and inflammation.Cellular and molecular life sciences : CMLS · 2016Review
- Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses.Cell reports · 2015Article
- Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.Immunity · 2015Article
- Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.Cell · 2014Article
- Macrophages in intestinal homeostasis and inflammation.Immunological reviews · 2014Review
- Contextual functions of antigen-presenting cells in the gastrointestinal tract.Immunological reviews · 2014Review
- Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.Immunity · 2014Article
- Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.Science (New York, N.Y.) · 2014Article
- Ontogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα.Frontiers in immunology · 2014Article
- Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.The Journal of experimental medicine · 2013Article
- Intestinal commensal microbes as immune modulators.Cell host & microbe · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Present in all organs, mononuclear phagocytes consist of a heterogeneous population of hematopoietic cells whose main role is to ensure tissue homeostasis through their ability to scavenge cell debris, promote tissue repair and maintain tolerance to self-antigens while simultaneously inducing innate and adaptive immune responses against foreign antigens that breach the tissue. The intestinal mucosa is particularly exposed to foreign antigen, through constant exposure to high loads of commensal bacteria and dietary antigens as well as providing a site of entry for viral and bacterial pathogens. The molecular mechanisms that control the intestinal ability to distinguish between "innocuous" and "dangerous" antigens remains poorly understood although it is clear that mononuclear phagocytes play a key role in this process. This review highlights recent advances in our understanding of heterogeneous origin of the mononuclear phagocytes that inhabit the intestinal mucosa and discusses how developmental diversity allows for functional diversity to ensure intestinal integrity.
Indexed as
Identifiers
22562804What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.