ArticleJournal of inherited metabolic disease2013
Fertility and pregnancy in women affected by glycogen storage disease type I, results of a multicenter Italian study.
Article in Journal of inherited metabolic disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Successful surgical management of multiple hepatocellular adenomas in a young female patient with glycogen storage disease type Ia: a case report.Journal of medical case reports · 2026Article
- Spontaneous restoration of premature ovarian insufficiency and conception in a patient with glycogen storage disease type 1b managed with empagliflozin.Hormones (Athens, Greece) · 2025Article
- Placenta Pathologies in Two Patients With Glycogen Storage Disease Type Ia and Preeclampsia.JIMD reports · 2025Article
- People and Families Affected by Glycogen Storage Disease Type Ia: An Analysis of Narrative Accounts Written by Individuals Living with GSDIa and Their Caregivers.Journal of health economics and outcomes research · 2025Article
- Endocrine system disturbances in children with inherited metabolic diseases: a narrative review.Frontiers in endocrinology · 2025Review
- Endocrine involvement in hepatic glycogen storage diseases: pathophysiology and implications for care.Reviews in endocrine & metabolic disorders · 2024Review
- Development of hepatocellular adenomas in a patient with glycogen storage disease Ia treated with growth hormone therapy.JIMD reports · 2023Article
- Glycogen storage diseases: An update.World journal of gastroenterology · 2023Review
- Two successful pregnancies and first use of empagliflozin during pregnancy in glycogen storage disease type Ib.JIMD reports · 2022Article
- Contraceptive use in women with inherited metabolic disorders: a retrospective study and literature review.Orphanet journal of rare diseases · 2022Review
- Glycogen Storage Disease Type Ia: Current Management Options, Burden and Unmet Needs.Nutrients · 2021Review
- Multidisciplinary management of pregnancy and labour in a patient with glycogen storage disease type 1a.BMJ case reports · 2021Article
- Reproduction in Animal Models of Lysosomal Storage Diseases: A Scoping Review.Frontiers in molecular biosciences · 2021Article
- Hormonal dysfunction in adult patients affected with inherited metabolic disorders.Journal of mother and child · 2020Review
- Glycogen metabolism and glycogen storage disorders.Annals of translational medicine · 2018Review
- Long-term complications of glycogen storage disease type Ia in the canine model treated with gene replacement therapy.Journal of inherited metabolic disease · 2018Article
- Impact of pregnancy on inborn errors of metabolism.Reviews in endocrine & metabolic disorders · 2018Review
- Tophaceous gout in a female premenopausal patient with an unexpected diagnosis of glycogen storage disease type Ia: a case report and literature review.Clinical rheumatology · 2016Review
- Natural Progression of Canine Glycogen Storage Disease Type IIIa.Comparative medicine · 2016Article
- Glycogen Storage Disease type 1a - a secondary cause for hyperlipidemia: report of five cases.Journal of diabetes and metabolic disorders · 2013Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLife expectancy of patients with glycogen storage disease (GSD) type I has improved considerably, opening new problems correlated with adult age. In females polycystic ovaries (PCOs) has been described as frequently associated with the disease, however successful pregnancies have been reported. Whether or not GSD I is associated with impaired reproductive function is still unclear. PATIENTS AND
methodsData about female patients with GSD Ia and Ib, who were 16 years or older, were obtained from clinical records and interviews.
resultsA total of 32 women with GSD I (25 GSD Ia, 7 GSD Ib), median age 26 years (range 16-55), were included. 9/32 patients had delayed menarche, 17/32 had irregular cycles, 8/22 had documented polycystic ovaries. Five successful spontaneous pregnancies in four patients with GSD Ia and two in a woman with GSD Ib were reported. The latter had development and enlargement of hepatic adenomas during pregnancies.
conclusionDespite the high prevalence of irregular menstruation cycles and polycystic ovaries, fertility seems not to be impaired in women with GSD I. During pregnancy monitoring for adenoma development is mandatory.
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