ArticleThe Plant cell2012
required to maintain repression2 is a novel protein that facilitates locus-specific paramutation in maize.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Identification of Proteins Associated with Stably Integrated MaizePlants (Basel, Switzerland) · 2025Article
- Paramutation at the maize pl1 locus is associated with RdDM activity at distal tandem repeats.PLoS genetics · 2024Article
- CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Locus-specific paramutation in Zea mays is maintained by a PICKLE-like chromodomain helicase DNA-binding 3 protein controlling development and male gametophyte function.PLoS genetics · 2020Article
- Exploring the extent and scope of epigenetic inheritance.Nature reviews. Endocrinology · 2018Review
- Paramutation and related phenomena in diverse species.Nature reviews. Genetics · 2017Review
- Article
- Trans-Homolog Interactions Facilitating Paramutation in Maize.Plant physiology · 2015Review
- Involvement of Multiple Gene-Silencing Pathways in a Paramutation-like Phenomenon in Arabidopsis.Cell reports · 2015Article
- Article
- Genetic perturbation of the maize methylome.The Plant cell · 2014Article
- Review
- Maize RNA polymerase IV defines trans-generational epigenetic variation.The Plant cell · 2013Article
- RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.Nature reviews. Genetics · 2013Review
- Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing.PLoS genetics · 2013Article
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Authors and funding
12 authors.
Funding
Abstract
Meiotically heritable epigenetic changes in gene regulation known as paramutations are facilitated by poorly understood trans-homolog interactions. Mutations affecting paramutations in maize (Zea mays) identify components required for the accumulation of 24-nucleotide RNAs. Some of these components have Arabidopsis thaliana orthologs that are part of an RNA-directed DNA methylation (RdDM) pathway. It remains unclear if small RNAs actually mediate paramutations and whether the maize-specific molecules identified to date define a mechanism distinct from RdDM. Here, we identify a novel protein required for paramutation at the maize purple plant1 locus. This required to maintain repression2 (RMR2) protein represents the founding member of a plant-specific clade of predicted proteins. We show that RMR2 is required for transcriptional repression at the Pl1-Rhoades haplotype, for accumulation of 24-nucleotide RNA species, and for maintenance of a 5-methylcytosine pattern distinct from that maintained by RNA polymerase IV. Genetic tests indicate that RMR2 is not required for paramutation occurring at the red1 locus. These results distinguish the paramutation-type mechanisms operating at specific haplotypes. The RMR2 clade of proteins provides a new entry point for understanding the diversity of epigenomic control operating in higher plants.
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