ArticleExperimental brain research2012
Effect of aging on ultrasonic vocalizations and laryngeal sensorimotor neurons in rats.
Article in Experimental brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Hypoglossal and lumbar motor neuron death in old Sprague-Dawley rats.Physiological reports · 2026Article
- The evidence for old age motor neuron death: A scoping review.Physiological reports · 2026Article
- Tongue blade neuromuscular junction defects in old F344 rats.Respiratory physiology & neurobiology · 2026Article
- Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior.Neurobiology of aging · 2025Article
- Dendritic alterations precede age-related dysphagia and nucleus ambiguus motor neuron death.The Journal of physiology · 2025Article
- Tongue and laryngeal exercises improve tongue strength and vocal function outcomes in a Pink1-/- rat model of early Parkinson disease.Behavioural brain research · 2024Article
- Positron emission tomography neuroimaging of [Frontiers in neuroscience · 2024Article
- Dendritic morphology of motor neurons and interneurons within the compact, semicompact, and loose formations of the rat nucleus ambiguus.Frontiers in cellular neuroscience · 2024Article
- Changes in ultrasonic vocalizations after unilateral cerebral ischemia in a rat stroke model.Behavioural brain research · 2023Article
- Effects of social isolation on 50-kHz ultrasonic vocalizations, affective state, cognition, and neurotransmitter concentrations in the ventral tegmental and locus coeruleus of adult rats.Behavioural brain research · 2023Article
- Early ultrasonic vocalization deficits and related thyroarytenoid muscle pathology in the transgenic TgF344-AD rat model of Alzheimer's disease.Frontiers in behavioral neuroscience · 2023Article
- Acoustilytix™: A Web-Based Automated Ultrasonic Vocalization Scoring Platform.Brain sciences · 2021Article
- Effect of Neuropeptide S Administration on Ultrasonic Vocalizations and Behaviour in Rats with Low vs. High Exploratory Activity.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Biological and Acoustic Sex Differences in Rat Ultrasonic Vocalization.Brain sciences · 2021Review
- Effects of Vocal Training on Thyroarytenoid Muscle Neuromuscular Junctions and Myofibers in Young and Older Rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Spontaneous Ultrasonic Vocalization Transmission in Adult, Male Long-Evans Rats Is Age-Dependent and Sensitive to EtOH Modulation.Brain sciences · 2020Article
- Preparation of the Rat Vocal Fold for Neuromuscular Analyses.Journal of visualized experiments : JoVE · 2020Article
- Recurrent laryngeal nerve transection in mice results in translational upper airway dysfunction.The Journal of comparative neurology · 2020Article
- Rapid development of mature vocal patterns of ultrasonic calls in a fast-growing rodent, the yellow steppe lemming (Eolagurus luteus).PloS one · 2020Article
- Geriatric Dysphonia: Etiological Analysis in a Rural Hospital in India.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2019Article
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3 authors.
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Abstract
While decline in vocal quality is prevalent in an aging population, the underlying neurobiological mechanisms contributing to age-related dysphonia are unknown and difficult to study in humans. Development of an animal model appears critical for investigating this issue. Using an established aging rat model, we evaluated if 50-kHz ultrasonic vocalizations in 10, 32-month-old (old) Fischer 344/Brown Norway rats differed from those in 10, 9-month-old (young adult) rats. The retrograde tracer, Cholera Toxin β, was injected to the thyroarytenoid muscle to determine if motoneuron loss in the nucleus ambiguus was associated with age. Results indicated that older rats had vocalizations with diminished acoustic complexity as demonstrated by reduced bandwidth, intensity, and peak frequency, and these changes were dependent on the type of 50-kHz vocalization. Simple calls of old rats had reduced bandwidth, peak frequency, and intensity while frequency-modulated calls of old rats had reduced bandwidth and intensity. Surprisingly, one call type, step calls, had increased duration in the aged rats. These findings reflect phonatory changes observed in older humans. We also found significant motoneuron loss in the nucleus ambiguus of aged rats, which suggests that motoneuron loss may be a contributing factor to decreased complexity and quality of ultrasonic vocalizations. These findings suggest that a rat ultrasonic phonation model may be useful for studying age-related changes in vocalization observed in humans.
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