ArticleDigestive diseases and sciences2012
Nanog: a potential biomarker for liver metastasis of colorectal cancer.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Dormancy in Colorectal Carcinoma: Detection and Therapeutic Potential.Biomolecules · 2025Review
- Combined treatment using bismuth sulfide nanoparticles loaded with NANOG decoy oligodeoxynucleotides under X-ray radiation for breast cancer cells.Scientific reports · 2025Article
- Review
- KRAB-ZFPs and cancer stem cells identity.Genes & diseases · 2023Review
- METTL14 suppresses cancer stem cell phenotype of colorectal cancer via regulating of β-catenin/NANOG.Journal of Cancer · 2023Article
- NANOG regulates epithelial-mesenchymal transition via AMPK/mTOR signalling pathway in ovarian cancer SKOV-3 and A2780 cells.Journal of cellular and molecular medicine · 2022Article
- Prognostic implication of SOX2 expression in small intestinal adenocarcinoma.Virchows Archiv : an international journal of pathology · 2021Article
- Far Beyond Cancer Immunotherapy: Reversion of Multi-Malignant Phenotypes of Immunotherapeutic-Resistant Cancer by Targeting the NANOG Signaling Axis.Immune network · 2020Review
- LASP1 induces colorectal cancer proliferation and invasiveness through Hippo signaling and Nanog mediated EMT.American journal of translational research · 2020Article
- Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients.Molecular & cellular oncology · 2020Article
- Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies.Frontiers in immunology · 2020Review
- Review
- Hypoxia promotes proliferation of pituitary adenomas by HIF-1α/ALKBH5 signalingInternational journal of clinical and experimental pathology · 2020Article
- PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis.Cancer research · 2019Article
- Review
- Cancer stem cells in progression of colorectal cancer.Oncotarget · 2018Review
- Article
- Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma.Oncotarget · 2017Article
- Stemness-Related Markers in Cancer.Cancer translational medicine · 2017Article
- Liver metastatic disease: new concepts and biomarker panels to improve individual outcomes.Clinical & experimental metastasis · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAt present, the relationship between Nanog expression and the biological behavior and prognosis of colorectal cancer is still unclear.
aimThe purpose of this study was to evaluate the expression and regulatory effects of Nanog in colorectal cancer and the correlation between Nanog protein expression and the prognosis of patients with colorectal cancer. MATERIALS AND
methodsThe differential expression of genes between CD133+ tumor cells and CD133- tumor cells were detected using RT(2) Profiler™ PCR Array. The Nanog mRNA expression level was detected by RT-PCR and the protein level was detected using immunohistochemistry staining. The relationship between Nanog expression and clinicopathological parameters of colorectal cancer was determined.
resultsNanog were expressed significantly higher in CD133+ tumor cells compared to CD133- tumor cells. It was observed that 72 (20.00 %) of the 360 cases positively expressed Nanog. Univariate analyses indicated that Nanog expression was related to histological grade, lymph node metastasis, TNM stage, and liver metastasis (P = 0.005, 0.001, 0.001 and 0.012, respectively). Spearman correlation analysis showed that Nanog expression has a linear correlation to liver metastasis (P = 0.001). After conducting multivariate analysis, histological grade, TNM stage, and Nanog were found to be related to liver metastasis (P = 0.020, 0.01 and 0.001, respectively). In the Cox regression test, the histological grade, Lymph node metastasis, TNM stage, liver metastasis, and Nanog were detected as the independent prognostic factors (P = 0.02, 0.045, 0.01, 0.001 and 0.001, respectively).
conclusionsNanog protein may be a potential biomarker for postoperative liver metastasis of colorectal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.