ArticleInvestigative ophthalmology & visual science2012
Responses of cells in the midbrain near-response area in monkeys with strabismus.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 60 citations in OpenAlex.
- Machine Learning-Based Prediction of Strabismus with and without Amblyopia from Fixation Eye Movements.Ophthalmology science · 2026Article
- Amblyopia Severity Predicts Fixation Dysfunction Independent of Nystagmus and Foveation Disruption in Fusion Maldevelopment Nystagmus.Investigative ophthalmology & visual science · 2026Article
- Differential Fixation and Eye Alignment Patterns in Strabismus with and Without Amblyopia Across Viewing Conditions.Journal of eye movement research · 2026Article
- Neural Innervation of Cyclovertical Extraocular Muscles During Asymmetric Vertical Vergence.Investigative ophthalmology & visual science · 2026Article
- Saccade-Related Activity in Superior Colliculus Predicts Eye Choice for Goal-Directed Saccades in Monkeys With Strabismus.Investigative ophthalmology & visual science · 2025Article
- Brainstem sources of input to the central mesencephalic reticular formation in the macaque.Experimental brain research · 2023Article
- Monitoring Eye Movement in Patients with Parkinson's Disease: What Can It Tell Us?Eye and brain · 2023Review
- Objective assessment of eye alignment and disparity-driven vergence in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Microstimulation of Interstitial Nucleus of Cajal Evokes Directionally Disconjugate Eye Movements in Monkeys With Pattern Strabismus.Investigative ophthalmology & visual science · 2022Article
- A Novel Tectal/Pretectal Population of Premotor Lens Accommodation Neurons.Investigative ophthalmology & visual science · 2022Article
- Computational models to delineate 3D gaze-shift strategies in Parkinson's disease.Journal of neural engineering · 2021Article
- Fixation eye movement abnormalities and stereopsis recovery following strabismus repair.Scientific reports · 2021Article
- Cerebellar projections to the macaque midbrain tegmentum: Possible near response connections.Visual neuroscience · 2021Article
- Neural control of rapid binocular eye movements: Saccade-vergence burst neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Is Primate Lens Accommodation Unilaterally or Bilaterally Controlled?Investigative ophthalmology & visual science · 2020Article
- Correlation between Ocular and Vestibular Abnormalities and Convergence Insufficiency in Post-Concussion Syndrome.Neuro-ophthalmology (Aeolus Press) · 2020Article
- Abnormal Tuning in Nucleus Prepositus Hypoglossi of Monkeys With "A" Pattern Exotropia.Investigative ophthalmology & visual science · 2020Article
- Longitudinal Development of Ocular Misalignment in Nonhuman Primate Models for Strabismus.Investigative ophthalmology & visual science · 2020Article
- Pupillary light reflex circuits in the macaque monkey: the preganglionic Edinger-Westphal nucleus.Brain structure & function · 2020Article
- Response Properties of Cells Within the Rostral Superior Colliculus of Strabismic Monkeys.Investigative ophthalmology & visual science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate whether neuronal activity within the supraoculomotor area (SOA-monosynaptically connected to medial rectus motoneurons and encode vergence angle) of strabismic monkeys was correlated with the angle of horizontal misalignment and therefore helps to define the state of strabismus.
methodsSingle-cell neural activity was recorded from SOA neurons in two monkeys with exotropia as they performed eye movement tasks during monocular viewing.
resultsHorizontal strabismus angle varied depending on eye of fixation (dissociated horizontal deviation) and the activity of SOA cells (n = 35) varied in correlation with the angle of strabismus. Both near-response (cells that showed larger firing rates for smaller angles of exotropia) and far-response (cells that showed lower firing rates for smaller angles of exotropia) cells were identified. SOA cells showed no modulation of activity with changes in conjugate eye position as tested during smooth-pursuit, thereby verifying that the responses were related to binocular misalignment. SOA cell activity was also not correlated with change in horizontal misalignment due to A-patterns of strabismus. Comparison of SOA population activity in strabismic animals and normal monkeys (described in the literature) show that both neural thresholds and neural sensitivities are altered in the strabismic animals compared with the normal animals.
conclusionsSOA cell activity is important in determining the state of horizontal strabismus, possibly by altering vergence tone in extraocular muscle. The lack of correlated SOA activity with changes in misalignment due to A/V patterns suggest that circuits mediating horizontal strabismus angle and those that mediate A/V patterns are different.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.