ArticleThe international journal of cardiovascular imaging2013
Diagnosis of viral myocarditis by cardiac magnetic resonance and viral genome detection in peripheral blood.
Article in The international journal of cardiovascular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- 2014 Korean guidelines for appropriate utilization of cardiovascular magnetic resonance imaging: a joint report of the Korean Society of Cardiology and the Korean Society of Radiology.Korean journal of radiologyGuideline
- Viral Myocarditis.The Yale journal of biology and medicine · 2024Review
- Review
- Patterns of cardiovascular magnetic resonance inflammation in acute myocarditis from South Asia and Middle East.International journal of cardiology. Heart & vasculature · 2022Article
- Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes.Signal transduction and targeted therapy · 2020Review
- Artificial Intelligence and Myocardial Contrast Enhancement Pattern.Current cardiology reports · 2020Review
- Assessment of edema using STIR+ via 3D cardiovascular magnetic resonance imaging in patients with suspected myocarditis.Magma (New York, N.Y.) · 2017Article
- Patients with exercise-associated ventricular ectopy present evidence of myocarditis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Article
- Cardiovascular magnetic resonance techniques and findings in children with myocarditis: a multicenter retrospective study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Article
- Evaluation of the diagnostic work-up in children with myocarditis and idiopathic dilated cardiomyopathy.Pediatric cardiology · 2015Article
- New-Onset Myocarditis in an Immunocompetent Adult with Acute Metapneumovirus Infection.Case reports in medicine · 2015Article
- 2014 korean guidelines for appropriate utilization of cardiovascular magnetic resonance imaging: a joint report of the korean society of cardiology and the korean society of radiology.Korean circulation journal · 2014Review
- Combined electrocardiography, coronary angiography and magnetic resonance imaging for the diagnosis of viral myocarditis: A case report.Experimental and therapeutic medicine · 2014Article
- Cardiovascular imaging 2013 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2014Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with acute myocarditis, viral genome can be detected in plasma and peripheral leukocytes. Its relationship with active myocardial inflammation, however, is not well understood. Myocardial edema as a feature of inflammation and myocardial necrosis or fibrosis can be frequently observed in patients with acute myocarditis by cardiovascular magnetic resonance (CMR). We assessed the association of viral genome presence in peripheral blood samples with myocardial edema and irreversible injury. We examined consecutive patients with clinically suspected myocarditis after an episode of viral illness. State-of-the-art methods were used for detecting myocardial edema and irreversible injury using CMR and viral genome applying reverse transcribed, nested polymerase chain reaction in peripheral blood samples. The specificity of viral amplification products was confirmed by automatic DNA sequencing. Of a total of 55 patients (53.5 ± 15.6 years), 21 were positive for viral genome in peripheral leukocytes. Interestingly, 18 (86%) of these patients also showed global myocardial edema, as compared to only 7/34 (21%) without PCR evidence for viral genome. The overall agreement between CMR criteria for edema and viral PCR was 84%. In contrast, there was no significant relationship of viral genome presence with myocardial necrosis or scars. In patients with clinically suspected myocarditis, myocardial edema but not irreversible myocardial injury is associated with the presence of viral genome in peripheral blood.
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