ArticleMolecular genetics and genomics : MGG2012
Whole-genome sequencing of the efficient industrial fuel-ethanol fermentative Saccharomyces cerevisiae strain CAT-1.
Article in Molecular genetics and genomics : MGG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Comparative functional genomics ofMicrobiology spectrum · 2026Article
- Automating the Illumina DNA library preparation kit for whole genome sequencing applications on the flowbot ONE liquid handler robot.Scientific reports · 2024Article
- Prospecting and engineering yeasts for ethanol production under inhibitory conditions: an experimental design analysis.Bioprocess and biosystems engineering · 2023Article
- Improved Sugarcane-Based Fermentation Processes by an Industrial Fuel-Ethanol Yeast Strain.Journal of fungi (Basel, Switzerland) · 2023Article
- Complete genome sequence and analysis of a Saccharomyces cerevisiae strain used for sugarcane spirit production.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- NaturalFrontiers in microbiology · 2021Article
- Comparative Genomics Supports That Brazilian BioethanolFrontiers in microbiology · 2021Article
- Evaluation of the Fermentative Capacity ofIndian journal of microbiology · 2020Article
- Adaptation to Industrial Stressors Through Genomic and Transcriptional Plasticity in a Bioethanol Producing Fission Yeast Isolate.G3 (Bethesda, Md.) · 2020Article
- Physiological characterization of a new thermotolerant yeast strain isolated during Brazilian ethanol production, and its application in high-temperature fermentation.Biotechnology for biofuels · 2020Article
- Controlled Reduction of Genomic Heterozygosity in an Industrial Yeast Strain Reveals Wide Cryptic Phenotypic Variation.Frontiers in genetics · 2019Article
- A study on the use of strain-specific and homologous promoters for heterologous expression in industrial Saccharomyces cerevisiae strains.AMB Express · 2018Article
- Industrial antifoam agents impair ethanol fermentation and induce stress responses in yeast cells.Applied microbiology and biotechnology · 2017Article
- Draft Genome Sequence ofGenome announcements · 2017Article
- Ethanol production in Brazil: a bridge between science and industry.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016Review
- Genome Sequence and Analysis of a Stress-Tolerant, Wild-Derived Strain of Saccharomyces cerevisiae Used in Biofuels Research.G3 (Bethesda, Md.) · 2016Article
- Next-generation sequencing analysis of lager brewing yeast strains reveals the evolutionary history of interspecies hybridization.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Draft Genome Sequence of Saccharomyces cerevisiae Strain NCIM3186 Used in the Production of Bioethanol from Sweet Sorghum.Genome announcements · 2015Article
- Genome Sequence of Saccharomyces cerevisiae NCIM3107, Used in Bioethanol Production.Genome announcements · 2015Article
- Deconstructing the genetic basis of spent sulphite liquor tolerance using deep sequencing of genome-shuffled yeast.Biotechnology for biofuels · 2015Article
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Authors and funding
15 authors.
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Abstract
The Saccharomyces cerevisiae strains widely used for industrial fuel-ethanol production have been developed by selection, but their underlying beneficial genetic polymorphisms remain unknown. Here, we report the draft whole-genome sequence of the S. cerevisiae strain CAT-1, which is a dominant fuel-ethanol fermentative strain from the sugarcane industry in Brazil. Our results indicate that strain CAT-1 is a highly heterozygous diploid yeast strain, and the ~12-Mb genome of CAT-1, when compared with the reference S228c genome, contains ~36,000 homozygous and ~30,000 heterozygous single nucleotide polymorphisms, exhibiting an uneven distribution among chromosomes due to large genomic regions of loss of heterozygosity (LOH). In total, 58 % of the 6,652 predicted protein-coding genes of the CAT-1 genome constitute different alleles when compared with the genes present in the reference S288c genome. The CAT-1 genome contains a reduced number of transposable elements, as well as several gene deletions and duplications, especially at telomeric regions, some correlated with several of the physiological characteristics of this industrial fuel-ethanol strain. Phylogenetic analyses revealed that some genes were likely associated with traits important for bioethanol production. Identifying and characterizing the allelic variations controlling traits relevant to industrial fermentation should provide the basis for a forward genetics approach for developing better fermenting yeast strains.
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