Evidence map›Paper›PMID 22562031›Full record

ArticleIranian biomedical journal2012

Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acids.

Korosh Khanaki, Mohammad Nouri, Ali M Ardekani, Alieh Ghassemzadeh, Vahideh Shahnazi, Mohammad R Sadeghi, Masoud Darabi, Amir Mehdizadeh, Homayon Dolatkhah, Abotaleb Saremi and 2 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian biomedical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03991520 early_phase1unknown statusnot on this mapstarted 2020, after this paper: background citation

Pilot Study of the IL-1 Antagonist Anakinra for the Treatment of Endometriosis Related Symptoms

TypeinterventionalSponsorUniversity of California, San DiegoRan2020 to 2022Enrolled20ConditionsEndometriosis, Anakinra, Markers of InflammationArmsAnakinra 100Mg/0.67Ml Inj Syringe, Placebo
NCT05175248 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2022 to 2029Enrolled120ConditionsEndometriosisArmsPlant-based Intervention Group
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Blood biomarkers for the non-invasive diagnosis of endometriosis.The Cochrane database of systematic reviews · 2016
    Pooled it
  3. Article
  4. Review
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  11. Review
  12. Review
  13. Review
  14. Does Nutrition Affect Endometriosis?Geburtshilfe und Frauenheilkunde · 2021
    Article
  15. Review
  16. Article
  17. Review
  18. Serum Polyunsaturated Fatty Acids and Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2015
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Korosh KhanakiDept. of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad NouriWomen’s Reproductive Health Research Center, Alzahra Hospital, Tabriz, Iran.
Ali M ArdekaniReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Alieh GhassemzadehWomen’s Reproductive Health Research Center, Alzahra Hospital, Tabriz, Iran.
Vahideh ShahnaziWomen’s Reproductive Health Research Center, Alzahra Hospital, Tabriz, Iran.
Mohammad R SadeghiMonoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Masoud DarabiDept. of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Amir MehdizadehDept. of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Homayon DolatkhahDept. of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Abotaleb SaremiSarem Cell Research Center (SCRC), Sarem Women's Hosp, Tehran, Iran.
Ali R ImaniDept. of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ali RahimipourDept. of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IRAcademic Center for Education, Culture and Research · IRBiotechnology Research Center · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometriosis is a common chronic inflammation causing major problems including infertility. The role of omega-3 and omega-6 fatty acids as their potential anti-inflammatory effects in endometriosis needs to be further explored. The objective of this study was to compare serum phospholipid fatty acid profile in endometriosis patients with controls, and to explore the correlation of this profile with the severity of the disease.

methodsSixty-four endometriosis patients and 74 control women, in reproductive age, participated in this study. Among the endometriosis patients, 19 cases were in stage I, 27 cases in stage II, 8 cases in stage III, and 10 cases in stage IV. Each patient underwent laparoscopy. Before surgery, 5 ml of blood was obtained. After extraction of the total lipids, serum total phospholipid fraction was isolated by thin layer chromatography. Fatty acid composition of the phospholipid fraction was determined by gas chromatography and the resulted profile was compared in endometriosis patients and controls. The profile was also compared in the endometriosis group based on the severity of disease.

resultsStearic acid was significantly lower in the endometriosis group as compared to controls (P= 0.030). No other fatty acid compositions were significantly different between patients and controls. Serum ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) was in reasonable correlation with the severity of endometriosis (r = 0.34, P = 0.006).

conclusionAccording to these findings, levels of fatty acids in serum total phospholipids seem not to be a marker for endometriosis, but the EPA to AA ratio was a relevant factor indicating severity of illness.

Indexed as

AdolescentAdultArachidonic AcidBiomarkersEicosapentaenoic AcidEndometriosisFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansInflammationInflammation MediatorsYoung AdultArachidonic AcidBiomarkersEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, Omega-6Inflammation MediatorsEndometriosisOmega-3 fatty acidsPhospholipids

Identifiers

PMID22562031
PMCPMC3614254
OpenAlexW2130406426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.