ArticleIranian biomedical journal2012
Delivery of epidermal neural crest stem cells (EPI-NCSC) to hippocamp in Alzheimer's disease rat model.
Article in Iranian biomedical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects of stem cell transplantation on cognitive decline in animal models of Alzheimer's disease: A systematic review and meta-analysis.Scientific reports · 2015Pooled it
- Comparative gene expression analysis of nestin-expressing hair follicle-derived cells.Scientific reports · 2026Article
- Neuroprotective and Immunomodulatory effects of human hair follicle stem cells on streptozotocin-induced memory impairment in rats: insights into inflammation and neurotrophic mechanisms.Molecular biology reports · 2025Article
- Therapeutic Potential of Experimental Stereotactic Hippocampal Cell Transplant in the Management of Alzheimer's Disease.Journal of clinical medicine · 2025Review
- In Vitro differentiation of hair-follicle bulge stem cells into synaptophysin-expressing neurons: a potential new approach for neuro-regeneration.Human cell · 2024Article
- Effect of Metformin on Epidermal Neural Crest Stem Cells and Their Potential Application in Ameliorating Paclitaxel-induced Neurotoxicity Phenotype.Stem cell reviews and reports · 2024Article
- An update on stem cell and stem cell-derived extracellular vesicle-based therapy in the management of Alzheimer's disease.Heliyon · 2023Review
- Combination Therapy with Platelet-Rich Plasma and Epidermal Neural Crest Stem Cells Increases Treatment Efficacy in Vascular Dementia.Stem cells international · 2023Article
- Therapeutic potential of hair follicle-derived stem cell intranasal transplantation in a rat model of ischemic stroke.BMC neuroscience · 2022Article
- Transplanted hair follicle stem cells migrate to the penumbra and express neural markers in a rat model of cerebral ischaemia/reperfusion.Stem cell research & therapy · 2020Article
- Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.CNS neuroscience & therapeutics · 2020Article
- Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive ImpairmentIranian biomedical journal · 2019Article
- In vitro induction effect of 1,25(OH)Biomedical journal · 2017Article
- Potential for Stem Cells Therapy in Alzheimer's Disease: Do Neurotrophic Factors Play Critical Role?Current Alzheimer research · 2017Review
- The role of biodegradable engineered random polycaprolactone nanofiber scaffolds seeded with nestin-positive hair follicle stem cells for tissue engineering.Advanced biomedical research · 2016Article
- Stem Cells in Neurological Disorders: Emerging Therapy with Stunning Hopes.Molecular neurobiology · 2015Review
- Hair follicle stem cells: In vitro and in vivo neural differentiation.World journal of stem cells · 2015Review
- In vitro neural differentiation of CD34 (+) stem cell populations in hair follicles by three different neural induction protocols.In vitro cellular & developmental biology. Animal · 2015Article
- The synergistic effects of heat shock protein 70 and ginsenoside Rg1 against tert-butyl hydroperoxide damage model in vitro.Oxidative medicine and cellular longevity · 2015Article
- Alzheimer's disease and stem cell therapy.Experimental neurobiology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlzheimer's disease (AD) is characterized by progressive neuronal loss in hippocamp. Epidermal neural crest stem cells (EPI-NCSC) can differentiate into neurons, astrocytes and oligodendrocytes. The purpose of this study was to evaluate the effects of transplanting EPI-NCSC into AD rat model.
methodsTwo weeks after induction of AD by injection of Amyloid-β1-40 into CA1 area of rat hippocamp, Y-maze and single-trial passive avoidance tests were used to show deficit of learning and memory abilities. EPI-NCSC were obtained from the vibrissa hair follicle of rat, cultured and labeled with bromodeoxyuridine. When Alzheimer was proved by behavioral tests, EPI-NCSC was transplanted into CA3 area of hippocamp in AD rat model. The staining of EPI-NCSC markers (nestin and SOX10) was done in vitro. Double-labeling immunofluorescence was performed to study survival and differentiation of the grafted cells.
resultsWe showed that transplanted EPI-NCSC survive and produce many neurons and a few glial cells, presenting glial fibrillary acidic protein. Total number of granule cells in hippocamp was estimated to be more in the AD rat model with transplanted cells as compared to AD control group. We observed that rats with hippocampal damage made more errors than control rats on the Y-maze, when reward locations were reversed.
conclusionTransplanted cells were migrated to all areas of hippocamp and the total number of granule cell in treatment group was equal compared to control group. Transplantation of EPI-NCSC into hippocamp might differentiate into cholinergic neurons and could cure impairment of memory in AD rat model.
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