ArticleNature methods2012
FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography.
Article in Nature methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed, 268 citations in OpenAlex.
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- High precision fluorescence tomography system for pre-clinical radiation research: system design and validation.Physics in medicine and biology · 2025Article
- Multi-Scale Volumetric Dynamic Optoacoustic and Laser Ultrasound (OPLUS) Imaging Enabled by Semi-Transparent Optical Guidance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions.Advanced drug delivery reviews · 2024Review
- Noninvasive Visualization of Amyloid-Beta Deposits in Alzheimer's Amyloidosis Mice via Fluorescence Molecular Tomography Using Contrast Agent.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Liver injury monitoring using dynamic fluorescence molecular tomography based on a time-energy difference strategy.Biomedical optics express · 2023Article
- Fluorescence-informed photoacoustic discrimination of multiple chromophores by lifetime mapping optically gated responses.Photoacoustics · 2023Article
- Reconstruction based on adaptive group least angle regression for fluorescence molecular tomography.Biomedical optics express · 2023Article
- Imaging drug delivery to the lungs: Methods and applications in oncology.Advanced drug delivery reviews · 2023Review
- Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform.Biomedical optics express · 2022Article
- Multi-branch attention prior based parameterized generative adversarial network for fast and accurate limited-projection reconstruction in fluorescence molecular tomography.Biomedical optics express · 2022Article
- In vivo accurate detection of the liver tumor with pharmacokinetic parametric images from dynamic fluorescence molecular tomography.Journal of biomedical optics · 2022Article
- Bioluminescence tomography reconstruction in conjunction with an organ probability map as an anatomical reference.Biomedical optics express · 2022Article
- A 4D x-ray computer microtomography for high-temperature electrochemistry.Science advances · 2022Article
- Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics.Frontiers in medicine · 2022Review
- A Hybrid Imaging Platform(CT/PET/FMI) for Evaluating Tumor Necrosis and Apoptosis in Real-Time.Frontiers in oncology · 2022Article
- L1-L2 norm regularization via forward-backward splitting for fluorescence molecular tomography.Biomedical optics express · 2021Article
- Mixing Matrix-corrected Whole-body Pharmacokinetic Modeling Using Longitudinal Micro-computed Tomography and Fluorescence-mediated Tomography.Molecular imaging and biology · 2021Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of hybrid optical tomography methods to improve imaging performance has been suggested over a decade ago and has been experimentally demonstrated in animals and humans. Here we examined in vivo performance of a camera-based hybrid fluorescence molecular tomography (FMT) system for 360° imaging combined with X-ray computed tomography (XCT). Offering an accurately co-registered, information-rich hybrid data set, FMT-XCT has new imaging possibilities compared to stand-alone FMT and XCT. We applied FMT-XCT to a subcutaneous 4T1 tumor mouse model, an Aga2 osteogenesis imperfecta model and a Kras lung cancer mouse model, using XCT information during FMT inversion. We validated in vivo imaging results against post-mortem planar fluorescence images of cryoslices and histology data. Besides offering concurrent anatomical and functional information, FMT-XCT resulted in the most accurate FMT performance to date. These findings indicate that addition of FMT optics into the XCT gantry may be a potent upgrade for small-animal XCT systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.