ReviewNature medicine2012
Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment.
Review in Nature medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
123 citing papers in PubMed, 5 syntheses or guidelines pooled it, 305 citations in OpenAlex.
- Impact of oral bacterial lysates on asthma control and immune parameters in children: evidence from an updated systematic review and meta-analysis of randomized trials.Frontiers in pharmacology · 2026Pooled it
- Association of fermented dairy consumption with asthma and wheeze risk in children: a systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2026Pooled it
- Association between asthma and dry eye disease: a meta-analysis based on observational studies.BMJ open · 2021Pooled it
- Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.Nature communications · 2020Pooled it
- Significant association between GSTT1 null genotype and risk of asthma during childhood in Caucasians.Molecular biology reports · 2013Pooled it
- Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness.PloS one · 2015Trial
- Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Trial
- Early Intervention With Biologics for Asthma Remission: Promising or Premature?Respirology (Carlton, Vic.) · 2026Article
- Beyond Infection-Indoor Airborne Pathogens as Contributors to Respiratory Inflammation and Immune Dysregulation: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Respiratory Pathogens and Clinical Characteristics of Asthma Exacerbations in Hospitalized Children at a Tertiary Hospital in Türkiye.Children (Basel, Switzerland) · 2026Article
- Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children.Allergy · 2026Article
- Association of maternal dietary diversity during pregnancy and infant lower respiratory tract infections.Pediatric research · 2026Article
- Immunological Mechanisms Underlying Allergy Predisposition After SARS-CoV-2 Infection in Children.Cells · 2025Review
- Article
- Atopy-related immune profiles are subject to genetic influence as evaluated using school-aged twin pairs.Science advances · 2025Article
- Catalase-encapsulated matrix metalloproteinase-9 responsive nanogels for modulation of inflammatory response and treatment of neutrophilic asthma.Journal of nanobiotechnology · 2025Article
- Dysregulation of airway and systemic interferon responses promotes asthma exacerbations in urban children.The Journal of allergy and clinical immunology · 2025Article
- An analysis of the global burden of childhood and adolescent asthma attributable to high BMI: 1990-2021.Frontiers in pediatrics · 2025Article
- Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma.Nature communications · 2024Article
- Extracellular Vesicle microRNA: A Promising Biomarker and Therapeutic Target for Respiratory Diseases.International journal of molecular sciences · 2024Review
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prospective birth cohort studies tracking asthma initiation and consolidation in community cohorts have identified viral infections occurring against a background of allergic sensitization to aeroallergens as a uniquely potent risk factor for the expression of acute severe asthma-like symptoms and for the ensuing development of asthma that can persist through childhood and into adulthood. A combination of recent experimental and human studies have suggested that underlying this bipartite process are a series of interactions between antiviral and atopic inflammatory pathways that are mediated by local activation of myeloid cell populations in the airway mucosa and the parallel programming and recruitment of their replacements from bone marrow. Targeting key components of these pathways at the appropriate stages of asthma provides new opportunities for the treatment of established asthma but, more crucially, for primary and secondary prevention of asthma during childhood.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.