ArticleNature medicine2012
King of hearts: a splicing factor rules cardiac proteins.
Article in Nature medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Alternative splicing factors and cardiac disease: more than just missplicing?RNA (New York, N.Y.) · 2025Article
- RNA binding proteins as mediators of pathological cardiac remodeling.Frontiers in cell and developmental biology · 2024Review
- The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes.Physiological reports · 2021Article
- Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.Nature medicine · 2020Article
- Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity.Nature communications · 2018Article
- RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure.The Journal of clinical investigation · 2016Article
- Review
- Heart failure with preserved ejection fraction.Pflugers Archiv : European journal of physiology · 2014Review
- Global impact of RNA splicing on transcriptome remodeling in the heart.Journal of Zhejiang University. Science. B · 2012Review
- Heart failure with preserved ejection fraction.Global cardiology science & practice · 2012Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).
Indexed as
Identifiers
22561820What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.