ReviewNeuroscience2013
Beyond counts and shapes: studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy.
Review in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex.iScience · 2025Article
- Morphology and Fractal-Based Classifications of Neurons and Microglia in Two and Three Dimensions.Advances in neurobiology · 2024Review
- Structural Diversity within the Endoplasmic Reticulum-From the Microscale to the Nanoscale.Cold Spring Harbor perspectives in biology · 2023Review
- Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus).Frontiers in aging neuroscience · 2023Article
- Synaptic alterations and neuronal firing in human epileptic neocortical excitatory networks.Frontiers in synaptic neuroscience · 2023Article
- Dendritic spinule-mediated structural synaptic plasticity: Implications for development, aging, and psychiatric disease.Frontiers in molecular neuroscience · 2023Review
- Comparative 2D and 3D Ultrastructural Analyses of Dendritic Spines from CA1 Pyramidal Neurons in the Mouse Hippocampus.International journal of molecular sciences · 2021Article
- Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.Neuron · 2020Article
- Synaptic Odyssey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives.Frontiers in psychiatry · 2020Review
- Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium.The Journal of general physiology · 2019Article
- The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study.Investigative ophthalmology & visual science · 2019Article
- Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus.Scientific reports · 2019Article
- Imaging neuronal structure dynamics using 2-photon super-resolution patterned excitation reconstruction microscopy.Journal of biophotonics · 2018Article
- Quantifying Golgi structure using EM: combining volume-SEM and stereology for higher throughput.Histochemistry and cell biology · 2017Review
- LTP enhances synaptogenesis in the developing hippocampus.Hippocampus · 2016Article
- Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex.Neural plasticity · 2016Article
- The human medial amygdala: structure, diversity, and complexity of dendritic spines.Journal of anatomy · 2015Article
- Large-scale automatic reconstruction of neuronal processes from electron microscopy images.Medical image analysis · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Because dendritic spines are the sites of excitatory synapses, pathological changes in spine morphology should be considered as part of pathological changes in neuronal circuitry in the forms of synaptic connections and connectivity strength. In the past, spine pathology has usually been measured by changes in their number or shape. A more complete understanding of spine pathology requires visualization at the nanometer level to analyze how the changes in number and size affect their presynaptic partners and associated astrocytic processes, as well as organelles and other intracellular structures. Currently, serial section electron microscopy (ssEM) offers the best approach to address this issue because of its ability to image the volume of brain tissue at the nanometer resolution. Renewed interest in ssEM has led to recent technological advances in imaging techniques and improvements in computational tools indispensable for three-dimensional analyses of brain tissue volumes. Here we consider the small but growing literature that has used ssEM analysis to unravel ultrastructural changes in neuropil including dendritic spines. These findings have implications in altered synaptic connectivity and cell biological processes involved in neuropathology, and serve as anatomical substrates for understanding changes in network activity that may underlie clinical symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.