ArticleBrain, behavior, and immunity2012
Individually ventilated cages cause chronic low-grade hypoxia impacting mice hematologically and behaviorally.
Article in Brain, behavior, and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- The behavioural consequences of dystrophinopathy.Disease models & mechanisms · 2025Article
- Mouse Testing Methods in Psychoneuroimmunology: Measuring Behavioral Responses.Methods in molecular biology (Clifton, N.J.) · 2025Article
- A Review of the Effects of Some Extrinsic Factors on Mice Used in Research.Comparative medicine · 2023Review
- Roadbumps at the Crossroads of Integrating Behavioral andFrontiers in toxicology · 2022Review
- Evaluation of Various IVC Systems According to Mouse Reproductive Performance and Husbandry and Environmental Parameters.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Housing mice in the individually ventilated or open cages-Does it matter for behavioral phenotype?Genes, brain, and behavior · 2019Article
- Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Occupational Animal Allergy.Current allergy and asthma reports · 2018Review
- Effect of Ventilated Caging on Water Intake and Loss in 4 Strains of Laboratory Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Nasal Histopathology and Intracage Ammonia Levels in Female Groups and Breeding Mice Housed in Static Isolation Cages.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Housing conditions modulate the severity of Mycoplasma pulmonis infection in mice deficient in class A scavenger receptor.Comparative medicine · 2014Article
- Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit.Life (Basel, Switzerland) · 2014Review
- Biological Effects of Space Radiation and Development of Effective Countermeasures.Life sciences in space research · 2014Article
- Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice.Psychoneuroendocrinology · 2013Article
- Mouse short- and long-term locomotor activity analyzed by video tracking software.Journal of visualized experiments : JoVE · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Use of individually ventilated caging (IVC) systems for mouse-based laboratory investigation has dramatically increased. We found that without mice present, intra-cage oxygen concentration was comparable (21%) between IVC housing and ambient environment caging (AEC) that used wire top lids. However, when mice were housed 4-to-a-cage for 1week, intra-cage oxygen dropped to 20.5% in IVC housing as compared to 21% for AEC housing. IVC intra-cage humidity was also elevated relative to AEC housing. Mice raised in IVC housing as compared to mice raised in AEC housing had higher RBC mass, hematocrit and hemoglobin concentrations. They also had elevated platelet counts but lower white blood cell counts. IVC mice, relative to AEC mice, had increased saccharin preference and increased fluid consumption but similar locomotion, food intake, social exploration and novel object recognition when tested in an AEC environment. Taken together, these data indicate that ventilated caging systems can have a 0.5% reduction from ambient oxygen concentration that is coupled to mouse red blood cell indices indicative of chronic exposure to a hypoxia. Importantly, IVC housing can impact behavioral testing for depressive-like behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.