ArticleBMJ open2012
Risk Factors for Alloimmunisation after red blood Cell Transfusions (R-FACT): a case cohort study.
Article in BMJ open, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01616329 (R-FACT Study), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
R-FACT Study:Risk Factors for Alloimmunization After Red Blood Cell Transfusions
Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Feasibility of Hemolytic Disease of the Fetus and Newborn Case Ascertainment and Assessing Its Impact on Prenatal and Postnatal Outcomes: Protocol for Observational Studies.JMIR research protocols · 2025Article
- Red Cell Phenotyping of Rh and Kell in Voluntary Blood Donors at a Tertiary Care Center in Jamnagar.Cureus · 2025Article
- The effect of extended c, E and K matching in females under 45 years of age on the incidence of transfusion-induced red blood cell alloimmunisation.British journal of haematology · 2021Article
- Association between renal failure and red blood cell alloimmunization among newly transfused patients.Transfusion · 2021Article
- Red blood cell alloimmunization in multi-transfused patients with chronic kidney disease in Port Harcourt, South-South Nigeria.African health sciences · 2018Article
- Transfusion Medicine and Molecular Genetic Methods.International journal of preventive medicine · 2018Review
- A Conceptual Framework for Optimizing Blood Matching Strategies: Balancing Patient Complications Against Total Costs Incurred.Frontiers in medicine · 2018Article
- Article
- Treatments for hematologic malignancies in contrast to those for solid cancers are associated with reduced red cell alloimmunization.Haematologica · 2017Article
- Red cell alloimmunisation in patients with different types of infections.British journal of haematology · 2016Article
- Frequencies and specificities of "enzyme-only" detected erythrocyte alloantibodies in patients hospitalized in austria: is an enzyme test required for routine red blood cell antibody screening?Journal of blood transfusion · 2014Article
- Red cell and human leukocyte antigen alloimmunization in candidates for renal transplantation: a reality.Revista brasileira de hematologia e hemoterapia · 2013Article
- "When less is more and more is less" red cell alloimmunization in multitransfused patients attending a medical institution with a newly developed blood center in North India: A multifactorial study.Asian journal of transfusion scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIndividuals exposed to red blood cell alloantigens through transfusion, pregnancy or transplantation may produce antibodies against the alloantigens. Alloantibodies can pose serious clinical problems such as delayed haemolytic reactions and logistic problems, for example, to obtain timely and properly matched transfusion blood for patients in which new alloantibodies are detected.
objectiveThe authors hypothesise that the particular clinical conditions (eg, used medication, concomitant infection, cellular immunity) during which transfusions are given may contribute to the risk of immunisation. The aim of this research was to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk against erythrocyte alloimmunisation during that transfusion episode. METHODS AND ANALYSIS STUDY
designIncident case-cohort study.
settingSecondary care, nationwide study (within the Netherlands) including seven hospitals, from January 2005 to December 2011. STUDY POPULATION: Consecutive red cell transfused patients at the study centres. INCLUSION: The study cohort comprises of consecutive red blood cell transfused patients at the study centre. EXCLUSION: Patients with transfusions before the study period and/or pre-existing alloantibodies.Cases defined as first time alloantibody formers; Controls defined as transfused individuals matched (on number of transfusions) to cases and have not formed an alloantibody. STATISTICAL ANALYSIS: Logistic regression models will be used to assess the association between the risk to develop antibodies and potential risk factors, adjusted for other risk factors. ETHICS AND DISSEMINATION: Approval at each local ethics regulatory committee will be obtained. Data will be coded for privacy reasons. Patients will be sent a letter and an information brochure explaining the purpose of the study. A consent form in presence of the study coordinator will be signed before the blood taking commences. Investigators will submit progress summary of the study to study sponsor regularly. Investigators will notify the accredited ethics board of the end of the study within a period of 8 weeks.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.