ArticleNeuroscience letters2012
Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex.
Article in Neuroscience letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Serum Neurofilament Light-Chain Concentrations in Essential Tremor: a Case-Control Study.Cerebellum (London, England) · 2024Article
- Elevated serum neurofilament light chain protein in patients with essential tremor.European journal of neurology · 2024Article
- Olaparib Attenuates Demyelination and Neuroinflammation in an Organotypic Slice Culture Model of Metachromatic Leukodystrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Serum NFL discriminates Parkinson disease from essential tremor and reflect motor and cognition severity.BMC neurology · 2022Article
- Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.International review of neurobiology · 2022Article
- Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Topological atlas of the hypothalamus in adult rhesus monkey.Brain structure & function · 2020Article
- Essential tremor pathology: neurodegeneration and reorganization of neuronal connections.Nature reviews. Neurology · 2020Review
- An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury.Free radical biology & medicine · 2019Article
- Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson's disease.Experimental brain research · 2017Article
- Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor.Brain : a journal of neurology · 2014Article
- From neurons to neuron neighborhoods: the rewiring of the cerebellar cortex in essential tremor.Cerebellum (London, England) · 2014Review
- Understanding essential tremor: progress on the biological front.Current neurology and neuroscience reports · 2014Review
- Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains.Brain : a journal of neurology · 2013Article
- Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau.Acta neuropathologica · 2013Article
- What is essential tremor?Current neurology and neuroscience reports · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Essential tremor (ET) is among the most prevalent neurological diseases. A substantial increase in the number of Purkinje cell axonal swellings (torpedoes) has been identified in ET brains. We recently demonstrated that torpedoes in ET contain an over-accumulation of disorganized neurofilament (NF) proteins. This now raises the question whether NF protein composition and/or phosphorylation state in cerebellar tissue might differ between ET cases and controls. We used a Western blot analysis to compare the levels and phosphorylation state of NF proteins and α-internexin in cerebellar tissue from 47 ET cases versus 26 controls (2:1 ratio). Cases and controls did not differ with respect to the cerebellar levels of NF-light (NF-L), NF-medium (NF-M), NF-heavy (NF-H), or α-internexin. However, SMI-31 levels (i.e., phosphorylated NF-H) and SMI-32 levels (i.e., non-phosphorylated NF-H) were significantly higher in ET cases than controls (1.28±0.47 vs. 1.06±0.32, p=0.02; and 1.38±0.75 vs. 1.00±0.42, p=0.006). Whether the abnormal phosphorylation state that we observed is a cause of defective axonal transport and/or function of NFs in ET is not known. NF abnormalities have been demonstrated in several neurodegenerative diseases. Regardless of whether these protein aggregates are the cause or consequence of these diseases, NF abnormalities have been shown to be an important factor in the cellular disruption observed in several neurodegenerative diseases. Therefore, further analyses of these NF abnormalities and their mechanisms are important to enhance our understanding of disease pathogenesis in ET.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.