Evidence map›Paper›PMID 22560837›Full record

ArticleBioorganic & medicinal chemistry2012

Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.

Cheng Ji, Weimin Lin, Garrett C Moraski, Jane A Thanassi, Michael J Pucci, Scott G Franzblau, Ute Möllmann, Marvin J Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Cheng JiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Weimin Lin
Garrett C Moraski
Jane A Thanassi
Michael J Pucci
Scott G Franzblau
Ute Möllmann
Marvin J Miller
University of Notre Dame · USAchillion Pharmaceuticals (United States) · USLeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversity of Illinois Chicago · US

Funding

Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
Bioactive Compounds from Acylnitroso CycloadductsR01GM068012 · NIGMS · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2003 to 2006
$1.2M
Novel Derivatization/Functionalization of Natural ProducR01GM075855 · NIGMS · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2005 to 2007
$1.0M
NIGMS NIH HHS GM 075885NIGMS NIH HHS GM 68012NIGMS NIH HHS R01 GM068012NIGMS NIH HHS R01 GM075855NIGMS NIH HHS T32 GM075762
6 · The paper itself

Abstract

Several novel oxazolidinone antibiotics with a spiropiperazinyl substituent at the 4'-position of the phenyl ring were synthesized through nitroso Diels-Alder chemistry and the in vitro antibacterial activities were evaluated against various Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and mycobacteria (Mycobacterium vaccae, Mycobacterium tuberculosis). Analogs (8a and 12) were active against selected drug resistant microbes, like methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) and had no mammalian toxicity in a Hep-2 cellular assay (CC(50) >100 μM).

Indexed as

Anti-Bacterial AgentsCell LineDrug Evaluation, PreclinicalDrug Resistance, BacterialEnterococcusEnterococcus faecalisGram-Negative BacteriaGram-Positive BacteriaHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructureMycobacteriumOxazolidinonesStaphylococcus aureusVancomycinAnti-Bacterial AgentsOxazolidinonesVancomycin

Identifiers

PMID22560837
PMCPMC3363956
OpenAlexW1999317519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.