Evidence map›Paper›PMID 22560576›Full record

ReviewPediatric clinics of North America2012

Pediatric scleroderma: systemic or localized forms.

Kathryn S Torok

Abstract readReview
In one paragraph

Review in Pediatric clinics of North America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Clinical Use and Molecular Action of Corticosteroids in the Pediatric Age.International journal of molecular sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Kathryn S TorokDivision of Rheumatology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA. Kathryn.Torok@chp.edu

Funding

T-helper cell cytokine profile in localized sclerodermaK23AR059722 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOROK, KATHRYN S. · 2010 to 2014
$629k
NIAMS NIH HHS K23 AR059722
6 · The paper itself

Abstract

Pediatric scleroderma includes 2 major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, their clinical manifestations differ. LS is typically confined to the skin and underlying subcutis, with up to a quarter of patients showing extracutaneous disease manifestations such as arthritis and uveitis. Vascular, cutaneous, gastrointestinal, pulmonary, and musculoskeletal involvement are most commonly seen in children with SSc. Treatment of both forms targets the active inflammatory stage and halts disease progression; however, progress needs to be made toward the development of more effective antifibrotic therapy to help reverse disease damage.

Indexed as

Scleroderma, LocalizedScleroderma, SystemicAnti-Inflammatory AgentsChildDermatologic AgentsHumansImmunosuppressive AgentsPrognosisTreatment OutcomeUltraviolet TherapyAnti-Inflammatory AgentsDermatologic AgentsImmunosuppressive Agents

Identifiers

PMID22560576
PMCPMC3459339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.