Trial reportThe Annals of thoracic surgery2012
Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress.
Trial report in The Annals of thoracic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine.JACC. Basic to translational science · 2023Article
- Computational modelling of multi-temporal ventricular-vascular interactions during the progression of pulmonary arterial hypertension.Journal of the Royal Society, Interface · 2022Article
- Left Ventricle Biomechanics of Low-Flow, Low-Gradient Aortic Stenosis: A Patient-Specific Computational Model.Frontiers in physiology · 2022Article
- The impact of myocardial compressibility on organ-level simulations of the normal and infarcted heart.Scientific reports · 2021Article
- False Tendon in Cardiovascular Diseases: Friend, Foe, or Bystander?Journal of cardiovascular imaging · 2021Article
- Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.Frontiers in physiology · 2020Article
- Optimizing Epicardial Restraint and Reinforcement Following Myocardial Infarction: Moving Towards Localized, Biomimetic, and Multitherapeutic Options.Biomimetics (Basel, Switzerland) · 2019Review
- Clinical manifestations, diagnosis, and treatment of ischemic mitral regurgitation: a review.Journal of thoracic disease · 2018Review
- Relationship of Transmural Variations in Myofiber Contractility to Left Ventricular Ejection Fraction: Implications for Modeling Heart Failure Phenotype With Preserved Ejection Fraction.Frontiers in physiology · 2018Article
- Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.Heart failure reviews · 2016Review
- Finite Element Modeling of Mitral Valve Repair.Journal of biomechanical engineering · 2016Review
- Residual Stress Impairs Pump Function After Surgical Ventricular Remodeling: A Finite Element Analysis.The Annals of thoracic surgery · 2015Article
- Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis.The Annals of thoracic surgery · 2014Article
- Bioinjection treatment: effects of post-injection residual stress on left ventricular wall stress.Journal of biomechanics · 2014Article
- Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Devices for mitral valve repair.Journal of cardiovascular translational research · 2014Review
- Mitral transcatheter technologies.Rambam Maimonides medical journal · 2013Article
- Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction.The Annals of thoracic surgery · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundWe sought to determine regional myofiber stress after Coapsys device (Myocor, Inc, Maple Grove, MN) implantation using a finite element model of the left ventricle (LV). Chronic ischemic mitral regurgitation is caused by LV remodeling after posterolateral myocardial infarction. The Coapsys device consists of a single trans-LV chord placed below the mitral valve such that when tensioned it alters LV shape and decreases chronic ischemic mitral regurgitation.
methodsFinite element models of the LV were based on magnetic resonance images obtained before (preoperatively) and after (postoperatively) coronary artery bypass grafting with Coapsys implantation in a single patient. To determine the effect of Coapsys and LV before stress, virtual Coapsys was performed on the preoperative model. Diastolic and systolic material variables in the preoperative, postoperative, and virtual Coapsys models were adjusted so that model LV volume agreed with magnetic resonance imaging data. Chronic ischemic mitral regurgitation was abolished in the postoperative models. In each case, myofiber stress and pump function were calculated.
resultsBoth postoperative and virtual Coapsys models shifted end-systolic and end-diastolic pressure-volume relationships to the left. As a consequence and because chronic ischemic mitral regurgitation was reduced after Coapsys, pump function was unchanged. Coapsys decreased myofiber stress at end-diastole and end-systole in both the remote and infarct regions of the myocardium. However, knowledge of Coapsys and LV prestress was necessary for accurate calculation of LV myofiber stress, especially in the remote zone.
conclusionsCoapsys decreases myofiber stress at end-diastole and end-systole. The improvement in myofiber stress may contribute to the long-term effect of Coapsys on LV remodeling.
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