ArticleAmerican journal of human genetics2012
Population demographic history can cause the appearance of recombination hotspots.
Article in American journal of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Article
- Computationally Efficient Demographic History Inference from Allele Frequencies with Supervised Machine Learning.Molecular biology and evolution · 2024Article
- Computationally efficient demographic history inference from allele frequencies with supervised machine learning.bioRxiv : the preprint server for biology · 2024Article
- Impact of feralization on evolutionary trajectories in the genomes of feral cat island populations.PloS one · 2024Article
- Recombination map tailored to Native Hawaiians may improve robustness of genomic scans for positive selection.Human genetics · 2024Article
- An exploration of linkage fine-mapping on sequences from case-control studies.Genetic epidemiology · 2023Article
- Article
- Inferring recombination patterns in African populations.Human molecular genetics · 2021Review
- High-resolution population-specific recombination rates and their effect on phasing and genotype imputation.European journal of human genetics : EJHG · 2021Article
- Reduced meiotic recombination in rhesus macaques and the origin of the human recombination landscape.PloS one · 2020Article
- Inference of recombination maps from a single pair of genomes and its application to ancient samples.PLoS genetics · 2019Article
- Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations.Science advances · 2019Article
- Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish.Genome biology and evolution · 2019Article
- LDJump: Estimating variable recombination rates from population genetic data.Molecular ecology resources · 2019Article
- Inference of population history using coalescent HMMs: review and outlook.Current opinion in genetics & development · 2018Review
- Effects of Demographic History on the Detection of Recombination Hotspots from Linkage Disequilibrium.Molecular biology and evolution · 2018Article
- Detecting Recombination Hotspots from Patterns of Linkage Disequilibrium.G3 (Bethesda, Md.) · 2016Article
- Two-Locus Likelihoods Under Variable Population Size and Fine-Scale Recombination Rate Estimation.Genetics · 2016Article
- New Software for the Fast Estimation of Population Recombination Rates (FastEPRR) in the Genomic Era.G3 (Bethesda, Md.) · 2016Article
- Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico.BMC genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Although the prevailing view among geneticists suggests that recombination hotspots exist ubiquitously across the human genome, there is only limited experimental evidence from a few genomic regions to support the generality of this claim. A small number of true recombination hotspots are well supported experimentally, but the vast majority of hotspots have been identified on the basis of population genetic inferences from the patterns of linkage disequilibrium (LD) seen in the human population. These inferences are made assuming a particular model of human history, and one of the assumptions of that model is that the effective population size of humans has remained constant throughout our history. Our results show that relaxation of the constant population size assumption can create LD and variation patterns that are qualitatively and quantitatively similar to human populations without any need to invoke localized hotspots of recombination. In other words, apparent recombination hotspots could be an artifact of variable population size over time. Several lines of evidence suggest that the vast majority of hotspots identified on the basis of LD information are unlikely to have elevated recombination rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.