Evidence map›Paper›PMID 22560074›Full record

ReviewCell stem cell2012

Tissue-specific stem cells: lessons from the skeletal muscle satellite cell.

Andrew S Brack, Thomas A Rando

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell stem cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 242 papers.

0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

242 citing papers in PubMed, 416 citations in OpenAlex.

  1. Article
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  12. Development of an anti-CDH15/M-cadherin monoclonal antibody CaBiochemistry and biophysics reports · 2025
    Article
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  14. Review
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182 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Andrew S BrackCenter of Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. abrack@partners.org
Thomas A Rando
Harvard University · USVA Palo Alto Health Care System · US

Funding

Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARGARET A. GOODELL · 2011 to 2026
$29.3M
Notch Signaling and Satellite Cell ActivationR37AG023806 · NIA · STANFORD UNIVERSITY · PI RANDO, THOMAS A. · 2010 to 2019
$2.9M
Quiescence of Muscle Stem Cells During Growth and RepairR01AR061002 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRACK, ANDREW S · 2012 to 2016
$1.7M
Muscle Satellite Cell Pool During AgingR01AR060868 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRACK, ANDREW S · 2011 to 2015
$1.7M
Molecular Regulation of Myogenic DifferentiationR01AR056849 · NIAMS · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A. · 2009 to 2013
$1.5M
The Function and Regulation of Pax3 in Muscle Stem CellsR01AR062185 · NIAMS · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A. · 2011 to 2015
$1.5M
NIAMS NIH HHS R01 AR056849NIAMS NIH HHS R01 AR060868NIAMS NIH HHS R01 AR061002NIAMS NIH HHS R01 AR062185NIA NIH HHS P01 AG036695NIA NIH HHS R37 AG023806NIA NIH HHS R37 AG23806
6 · The paper itself

Abstract

In 1961, the satellite cell was first identified when electron microscopic examination of skeletal muscle demonstrated a cell wedged between the plasma membrane of the muscle fiber and the basement membrane. In recent years it has been conclusively demonstrated that the satellite cell is the primary cellular source for muscle regeneration and is equipped with the potential to self renew, thus functioning as a bona fide skeletal muscle stem cell (MuSC). As we move past the 50(th) anniversary of the satellite cell, we take this opportunity to discuss the current state of the art and dissect the unknowns in the MuSC field.

Indexed as

Adult Stem CellsAnimalsCell DivisionGuided Tissue RegenerationHumansOrgan SpecificityRegenerative MedicineSatellite Cells, Skeletal MuscleSignal TransductionWound Healing

Identifiers

PMID22560074
PMCPMC3348769
OpenAlexW2083941402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.