ReviewSeminars in immunology2012
Genetic regulation of thymocyte progenitor aging.
Review in Seminars in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Immunosenescence in Older Patients with Psoriasis: Mechanistic Insights and Opportunities for Biologic Therapy.Psoriasis (Auckland, N.Z.) · 2026Review
- Age-related reduction of pyruvate dehydrogenase kinase 1 impairs T cell responses.Frontiers in immunology · 2026Article
- Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process.Immunity & ageing : I & A · 2024Article
- Immunosenescence and Aging: Neuroinflammation Is a Prominent Feature of Alzheimer's Disease and Is a Likely Contributor to Neurodegenerative Disease Pathogenesis.Journal of personalized medicine · 2022Review
- Dysregulation of Systemic Immunity in Aging and Dementia.Frontiers in cellular neuroscience · 2021Review
- Diminished immune responses with aging predispose older adults to common and uncommon influenza complications.Cellular immunology · 2019Review
- Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration.Nature communications · 2019Article
- Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Confluence of Sex Hormones and Aging on Immunity.Frontiers in immunology · 2018Review
- Lymphocyte generation and population homeostasis throughout life.Seminars in hematology · 2017Review
- Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution.Cell reports · 2014Article
- Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Understanding immunosenescence to improve responses to vaccines.Nature immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The number of T cell progenitors is significantly reduced in the involuted thymus, and the growth and developmental potential of the few cells that are present is severely attenuated. This review provides an overview of how aging affects T cell precursors before and following entry into the thymus and discusses the age-related genetic changes that may occur in them. Finally, interventions that rejuvenate thymopoiesis in the elderly by targeting T cell progenitors are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.