Trial reportJournal of palliative medicine2012
A nurse practitioner directed intervention improves the quality of life of patients with metastatic cancer: results of a randomized pilot study.
Trial report in Journal of palliative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 11 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Prognostic models for survival predictions in advanced cancer patients: a systematic review and meta-analysis.BMC palliative care · 2025Pooled it
- Pooled it
- Comparing Specialty and Primary Palliative Care Interventions: Analysis of a Systematic Review.Journal of palliative medicine · 2020Pooled it
- Multicomponent Palliative Care Interventions in Advanced Chronic Diseases: A Systematic Review.The American journal of hospice & palliative care · 2018Pooled it
- Early palliative care for adults with advanced cancer.The Cochrane database of systematic reviews · 2017Pooled it
- Implementing Evidence-Based Palliative Care Programs and Policy for Cancer Patients: Epidemiologic and Policy Implications of the 2016 American Society of Clinical Oncology Clinical Practice Guideline Update.Epidemiologic reviews · 2017Pooled it
- Pooled it
- Populations and Interventions for Palliative and End-of-Life Care: A Systematic Review.Journal of palliative medicine · 2016Pooled it
- A scoping review of the nurse practitioner workforce in oncology.Cancer medicine · 2016Pooled it
- Communication Tools for End-of-Life Decision-Making in Ambulatory Care Settings: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Reviewing cancer care team effectiveness.Journal of oncology practice · 2015Pooled it
- Timing Matters: A Systematic Review of Early Versus Delayed Palliative Care in Advanced Cancer.Cancers · 2025Review
- Cancer patients have a reduced likelihood of dying in hospital with advance care planning in primary health care and a summarizing palliative plan: a prospective controlled non-randomized intervention trial.Scandinavian journal of primary health care · 2024Article
- Psychological stress of general practitioners in the care of patients with palliative care needs: an exploratory study.BMC palliative care · 2024Article
- Article
- Clinical Experience of Nurses in a Consultative Hospice Palliative Care Service.Journal of hospice and palliative care · 2024Article
- Article
- What is an "early palliative care" intervention? A scoping review of controlled studies in oncology.Cancer medicine · 2023Article
- Validation Study of the PALCOM Scale of Complexity of Palliative Care Needs: A Cohort Study in Advanced Cancer Patients.Cancers · 2023Article
- Communication in the context of glioblastoma treatment: A qualitative study of what matters most to patients, caregivers and health care professionals.Palliative medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is a paucity of randomized studies evaluating the value of palliative interventions on a prospective basis in newly diagnosed oncology patients. We sought to prospectively evaluate quality of life (QoL) outcomes in advanced cancer patients who received discussion-based palliative care interventions from an advanced registered nurse practitioner (ARNP) integrated into the oncology team, and compare these outcomes with a control population.
methodsPatients with metastatic cancer were randomized to standard care or an ARNP-directed intervention that included discussions of the benefits of hospice, discussions on living wills and advanced directives (Five Wishes document) along with an assessment of QoL. Relevant endpoints included change from baseline QoL and improvement in hospice knowledge.
resultsFrom November 13, 2008, through July 28, 2009, 26 patients were accrued at the Mayo Clinic in Jacksonville, Florida. The study closed early due to published data demonstrating the benefits of early palliative care interventions in the management of metastatic cancer patients. Statistically significant improvements from baseline were noted in emotional and mental QoL assessments in the intervention group that were not seen in the control group. Patients found it useful to have the living will and Five Wishes documents offered as part of the ARNP intervention.
conclusionsAn ARNP-directed intervention that explains the benefits of hospice and addresses advanced directives early in the course of metastatic cancer patients' treatment, is well received by the patients and their relatives and leads to measurable improvement in the patient's emotional and mental QoL.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.