ArticleJournal of biomedical optics2012
In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesis.
Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Light scattering methods for tissue diagnosis.Optica · 2019Article
- Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer.BMC cancer · 2018Article
- Wide-field quantitative imaging of tissue microstructure using sub-diffuse spatial frequency domain imaging.Optica · 2016Article
- Subdiffusion reflectance spectroscopy to measure tissue ultrastructure and microvasculature: model and inverse algorithm.Journal of biomedical optics · 2015Article
- Sub-diffusive scattering parameter maps recovered using wide-field high-frequency structured light imaging.Biomedical optics express · 2014Article
- In vivo quantification of the scattering properties of tissue using multi-diameter single fiber reflectance spectroscopy.Biomedical optics express · 2013Article
- Can OCT be sensitive to nanoscale structural alterations in biological tissue?Optics express · 2013Article
- Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification.Journal of Cancer · 2013Article
- Analytical light reflectance models for overlapping illumination and collection area geometries.Applied optics · 2012Article
- Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence.Journal of biomedical optics · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polarization-gated spectroscopy is an established method to depth-selectively interrogate the structural properties of biological tissue. We employ this method in vivo in the azoxymethane (AOM)-treated rat model to monitor the morphological changes that occur in the field of a tumor during early carcinogenesis. The results demonstrate a statistically significant change in the shape of the refractive-index correlation function for AOM-treated rats versus saline-treated controls. Since refractive index is linearly proportional to mass density, these refractive-index changes can be directly linked to alterations in the spatial distribution patterns of macromolecular density. Furthermore, we found that alterations in the shape of the refractive-index correlation function shape were an indicator of both present and future risk of tumor development. These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development.
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