Evidence map›Paper›PMID 22559667›Full record

ArticleJournal of biomedical optics2012

Anisotropic light scattering of individual sickle red blood cells.

Youngchan Kim, John M Higgins, Ramachandra R Dasari, Subra Suresh, YongKeun Park

Abstract readLetter
In one paragraph

Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Biomedical optics express · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Youngchan Kim
John M Higgins
Ramachandra R Dasari
Subra Suresh
YongKeun Park

Funding

WIDE-FIELD REFLECTION PHASE MICROSCOPYP41RR002594 · NCRR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YOM, SUNG MI · 1985 to 2011
$12.3M
Multiscale Modeling and Parallel Simulations of Blood Flow in Cerebral Malaria anR01HL094270 · NHLBI · BROWN UNIVERSITY · PI KARNIADAKIS, GEORGE, SURESH, SUBRA · 2009 to 2011
$1.8M
Quantitative Analysis of Blood Flow in Sickle Cell DiseaseK08DK083242 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI HIGGINS, JOHN MATTHEW · 2008 to 2012
$796k
NCRR NIH HHS P41 RR002594NCRR NIH HHS P41-RR02594-18-24NHLBI NIH HHS R01 HL094270NHLBI NIH HHS R01HL094270NIDDK NIH HHS DK083242NIDDK NIH HHS K08 DK083242
6 · The paper itself

Abstract

We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs with arbitrary orientation, we introduce the anisotropic Fourier transform light scattering (aFTLS) technique and measured both the static and dynamic anisotropic light scattering. We observed strong anisotropy in light scattering patterns of elongated-shaped sickle RBCs along its major axes using static aFTLS. Dynamic aFTLS analysis reveals the significantly altered biophysical properties in individual sickle RBCs. These results provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs.

Indexed as

Scattering, RadiationAnemia, Sickle CellAnisotropyErythrocytesFourier AnalysisHumansLightSingle-Cell AnalysisViscosity

Identifiers

PMID22559667
PMCPMC3602817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.