ArticleBMC genomics2012
Genomic characterization of the conditionally dispensable chromosome in Alternaria arborescens provides evidence for horizontal gene transfer.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Horizontal transfer of accessory chromosomes in fungi - a regulated process for exchange of genetic material?Heredity · 2026Review
- Fungal MicroRNA-Like RNAs Facilitate Convergent Attack on a Host Immune Signalling Network.Plant, cell & environment · 2026Article
- Dual RNA-Seq Reveals Molecular Interactions BetweenFoods (Basel, Switzerland) · 2026Article
- Distribution and shared evolutionary history of the Fumonisin and AAL toxin biosynthetic gene clusters.BMC genomics · 2026Article
- Article
- Genome mining reveals the distribution of biosynthetic gene clusters in Alternaria and related fungal taxa within the family Pleosporaceae.BMC genomics · 2025Article
- Complete genome of the Medicago anthracnose fungus,Microbial genomics · 2024Article
- Alternaria diseases on potato and tomato.Molecular plant pathology · 2024Review
- Chromosome-scale assembly uncovers genomic compartmentation ofFrontiers in microbiology · 2023Article
- Review
- FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution.PLoS computational biology · 2021Article
- Article
- DNA sequencing, genomes and genetic markers of microbes on fruits and vegetables.Microbial biotechnology · 2021Review
- Accessory Chromosomes inPhytopathology · 2020Review
- Comparative genomics of Alternaria species provides insights into the pathogenic lifestyle of Alternaria brassicae - a pathogen of the Brassicaceae family.BMC genomics · 2019Article
- Genomic features and evolution of the conditionally dispensable chromosome in the tangerine pathotype of Alternaria alternata.Molecular plant pathology · 2019Article
- Article
- Genomics Evolutionary History and Diagnostics of theFrontiers in microbiology · 2019Article
- Genome-scale data resolve ancestral rock-inhabiting lifestyle in Dothideomycetes (Ascomycota).IMA fungus · 2019Article
- Quantitative sequence characterization for repetitive DNA content in the supernumerary chromosome of the migratory locust.Chromosoma · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFungal plant pathogens cause serious agricultural losses worldwide. Alternaria arborescens is a major pathogen of tomato, with its virulence determined by the presence of a conditionally dispensable chromosome (CDC) carrying host-specific toxin genes. Genes encoding these toxins are well-studied, however the genomic content and organization of the CDC is not known.
resultsTo gain a richer understanding of the molecular determinants of virulence and the evolution of pathogenicity, we performed whole genome sequencing of A. arborescens. Here we present the de-novo assembly of the CDC and its predicted gene content. Also presented is hybridization data validating the CDC assembly. Predicted genes were functionally annotated through BLAST. Gene ontology terms were assigned, and conserved domains were identified. Differences in nucleotide usage were found between CDC genes and those on the essential chromosome (EC), including GC3-content, codon usage bias, and repeat region load. Genes carrying PKS and NRPS domains were identified in clusters on the CDC and evidence supporting the origin of the CDC through horizontal transfer from an unrelated fungus was found.
conclusionsWe provide evidence supporting the hypothesis that the CDC in A. arborescens was acquired through horizontal transfer, likely from an unrelated fungus. We also identified several predicted CDC genes under positive selection that may serve as candidate virulence factors.
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