ArticleAnalytical chemistry2012
Ion mobility separation of variant histone tails extending to the "middle-down" range.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed.
- Review
- Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails.Journal of the American Society for Mass Spectrometry · 2019Article
- Recommendations for reporting ion mobility Mass Spectrometry measurements.Mass spectrometry reviews · 2019Review
- Middle-down approach: a choice to sequence and characterize proteins/proteomes by mass spectrometry.RSC advances · 2018Review
- A Novel Differential Ion Mobility Device Expands the Depth of Proteome Coverage and the Sensitivity of Multiplex Proteomic Measurements.Molecular & cellular proteomics : MCP · 2018Article
- Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms.Analytical chemistry · 2018Article
- Broad Separation of Isomeric Lipids by High-Resolution Differential Ion Mobility Spectrometry with Tandem Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Characterization of Complete Histone Tail Proteoforms Using Differential Ion Mobility Spectrometry.Analytical chemistry · 2017Article
- Toward an Optimized Workflow for Middle-Down Proteomics.Analytical chemistry · 2017Article
- Ion Mobility Separation of Peptide Isotopomers.Journal of the American Society for Mass Spectrometry · 2016Article
- To What Extent is FAIMS Beneficial in the Analysis of Proteins?Journal of the American Society for Mass Spectrometry · 2016Article
- Experimental evaluation and optimization of structures for lossless ion manipulations for ion mobility spectrometry with time-of-flight mass spectrometry.Analytical chemistry · 2014Article
- Differential ion mobility separations in up to 100% helium using microchips.Journal of the American Society for Mass Spectrometry · 2014Article
- Separation of protein conformers by differential ion mobility in hydrogen-rich gases.Analytical chemistry · 2013Article
- Proteomics in epigenetics: new perspectives for cancer research.Briefings in functional genomics · 2013Review
- High-definition differential ion mobility spectrometry with resolving power up to 500.Journal of the American Society for Mass Spectrometry · 2013Article
- Pushing the Frontier of High-Definition Ion Mobility Spectrometry Using FAIMS.Mass spectrometry (Tokyo, Japan) · 2013Article
- Separation of variant methylated histone tails by differential ion mobility.Analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Differential ion mobility spectrometry (FAIMS) can baseline-resolve multiple variants of post-translationally modified peptides extending to the 3-4 kDa range, which differ in the localization of a PTM as small as acetylation. Essentially orthogonal separations for different charge states expand the total peak capacity with the number of observed states that increases for longer polypeptides. This potentially enables resolving localization variants for yet larger peptides and even intact proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.